Morphogenesis of Experimental Infection Caused by Plasmid Variants of Yersinia pseudotuberculosis

The dynamics of pathomorphological changes in response to infection with plasmid variants of Yersinia pseudotuberculosis was studied in experimental animals. Variability of cell injuries in pseudotuberculosis histopathology depended on the plasmid-associated virulence of the infection agent. Infecti...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-12, Vol.162 (2), p.264-268
Main Authors: Somova, L. M., Drobot, E. I., Plekhova, N. G., Lyapun, I. N., Shubin, F. N.
Format: Article
Language:English
Subjects:
Animals
Animals, Outbred Strains
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cell Biology
Experimental infection
Genetic aspects
Health aspects
Hepatocytes - microbiology
Hepatocytes - pathology
Histochemistry
Humans
Infection
Infections
Injections, Intraperitoneal
Internal Medicine
Kupffer Cells - microbiology
Kupffer Cells - pathology
Laboratory Medicine
Liver - microbiology
Liver - pathology
Lung - microbiology
Lung - pathology
Lymph Nodes - microbiology
Lymph Nodes - pathology
Male
Mice
Morphogenesis
Necrosis - microbiology
Necrosis - pathology
Pathology
Phagocytes - microbiology
Phagocytes - pathology
Plasmids - chemistry
Plasmids - metabolism
Pseudotuberculosis
Species Specificity
Spleen - microbiology
Spleen - pathology
Virulence
Virulence (Microbiology)
Yersinia pseudotuberculosis
Yersinia pseudotuberculosis - genetics
Yersinia pseudotuberculosis - growth & development
Yersinia pseudotuberculosis - pathogenicity
Yersinia pseudotuberculosis Infections - microbiology
Yersinia pseudotuberculosis Infections - pathology
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Summary:The dynamics of pathomorphological changes in response to infection with plasmid variants of Yersinia pseudotuberculosis was studied in experimental animals. Variability of cell injuries in pseudotuberculosis histopathology depended on the plasmid-associated virulence of the infection agent. Infection with highly virulent two-plasmid strain pYV48:pVM82 MDa and Y. pseudotuberculosis strain with low virulence with the only plasmid pVM82 MDa led to the development of cell destruction (necrosis and apoptosis) in the target organs. Apoptosis predominated in response to infection by plasmid variant pVM82 MDa with low virulence.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3591-z