Synthesis of a disaccharide of phenolic glycolipid from Mycobacterium leprae (PGL-I) and its conjugates with bovine serum albumin

Terminal disaccharide fragment of phenolic glycolipid from Mycobacterium leprae (PGL-I) was synthesized as a glycoside with 4-(2-aminoethoxy)phenyl aglycon. The obtained 4-(2-aminoethoxy)phenyl 4- O -(3,6-di- O -methyl-β- d -glucopyranosyl)-2,3-di- O -methyl-α- l -rhamnopyranoside was used for the s...

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Bibliographic Details
Published in:Russian chemical bulletin 2015-05, Vol.64 (5), p.1142-1148
Main Authors: Kondakov, N. N., Mel´nikova, T. M., Chekryzhova, T. V., Mel´nikova, M. V., Zinin, A. I., Torgov, V. I., Chizhov, A. O., Kononov, L. O.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Mycobacterium leprae
Organic Chemistry
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Summary:Terminal disaccharide fragment of phenolic glycolipid from Mycobacterium leprae (PGL-I) was synthesized as a glycoside with 4-(2-aminoethoxy)phenyl aglycon. The obtained 4-(2-aminoethoxy)phenyl 4- O -(3,6-di- O -methyl-β- d -glucopyranosyl)-2,3-di- O -methyl-α- l -rhamnopyranoside was used for the synthesis of a series of neoglycoconjugates with bovine serum albumin with different degrees of substitution.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-015-0991-6