Effect of corneal collagen crosslinking on subsequent deep anterior lamellar keratoplasty (DALK) in keratoconus

Purpose The purpose was to investigate the impact of ultraviolet light corneal collagen crosslinking (UV-CXL) on the success rate and clinical outcome of subsequent deep anterior lamellar keratoplasty (DALK) in eyes with keratoconus (KC). Methods Medical records of 101 consecutive eyes with KC sched...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2017-04, Vol.255 (4), p.811-816
Main Authors: Schaub, Friederike, Enders, Philip, Bachmann, Björn O., Heindl, Ludwig M., Cursiefen, Claus
Format: Article
Language:English
Subjects:
Adult
Collagen - pharmacology
Cornea
Cornea - drug effects
Cornea - pathology
Cornea - surgery
Corneal Topography
Cross-Linking Reagents - pharmacology
Female
Follow-Up Studies
Germany - epidemiology
Humans
Incidence
Keratoconus - diagnosis
Keratoconus - drug therapy
Keratoconus - surgery
Keratoplasty, Penetrating - methods
Male
Medicine
Medicine & Public Health
Ophthalmology
Photochemotherapy - methods
Postoperative Complications - diagnosis
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
Retrospective Studies
Time Factors
Treatment Outcome
Visual Acuity
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Summary:Purpose The purpose was to investigate the impact of ultraviolet light corneal collagen crosslinking (UV-CXL) on the success rate and clinical outcome of subsequent deep anterior lamellar keratoplasty (DALK) in eyes with keratoconus (KC). Methods Medical records of 101 consecutive eyes with KC scheduled for big-bubble DALK surgery were screened retrospectively for details of previously performed UV-CXL, as well as intra- and postoperative complications of DALK surgery. Main outcome measures were intraoperative success rates (big-bubble formation, conversion to penetrating keratoplasty (PK)), postoperative complications, best corrected visual acuity (BCVA), endothelial cell density (ECD), and central corneal thickness (CCT) within 18 months of follow-up. Results Out of the 101 KC eyes, eight eyes (7.9%) had a history of previous UV-CXL. Surgical failure, defined as conversion to PK due to macroperforation, occurred in 17 eyes (16.8%) of 93 eyes without and in none with previous UV-CXL ( P  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-017-3592-2