A case of concomitant colitic cancer and intrahepatic cholangiocarcinoma during follow-up for ulcerative colitis

• Published in: Clinical journal of gastroenterology 2017-04, Vol.10 (2), p.157-162
• Main Authors: Tsuchiya, Kazuyo, Nanashima, Atsushi, Ikeda, Takuto, Minami, Shiro, Nagano, Motoaki, Hamada, Takeomi, Yano, Koichi, Fujii, Yoshiro
• Format: Article
• Language: English
• Subjects: Abdominal Surgery; Aged; Bile Duct Neoplasms - diagnostic imaging; Bile Duct Neoplasms - etiology; Bile Duct Neoplasms - surgery; Bile Ducts, Intrahepatic; Case Report; Cholangiocarcinoma - diagnostic imaging; Cholangiocarcinoma - etiology; Cholangiocarcinoma - surgery; Cholangitis, Sclerosing - complications; Colitis, Ulcerative - complications; Colonoscopy; Colorectal Surgery; Follow-Up Studies; Gastroenterology; Hepatectomy; Hepatology; Humans; Male; Medicine; Medicine & Public Health; Neoplasms, Multiple Primary - diagnosis; Neoplasms, Multiple Primary - etiology; Neoplasms, Multiple Primary - surgery; Rectal Neoplasms - diagnosis; Rectal Neoplasms - etiology; Rectal Neoplasms - surgery; Surgical Oncology; Tomography, X-Ray Computed
• ISSN: 1865-7257; 1865-7265
• DOI: 10.1007/s12328-017-0715-6

Colitis-associated colorectal cancer (CAC) is known to occur in long-standing and extensive ulcerative colitis (UC). Furthermore, UC is known to complicate primary sclerosing cholangitis (PSC), which subsequently results in an increased risk of developing cholangiocarcinoma. We report a case of colitis-associated rectal cancer (CARC) accompanied by intrahepatic cholangiocarcinoma (ICC) based on UC and PSC. A 73-year-old man had suffered from UC for 19 years. During surveillance colonoscopy, a tumor was found in the rectum that was pathologically diagnosed as CARC from the resected specimen. Abdominal computed tomography also revealed a localized dilation of the intrahepatic bile duct, and endoscopic retrograde cholangiography revealed a band-like stricture. This remarkable tumor lesion was not observed in the hepatic duct. Left hepatectomy was performed because of the suspicion of possible ICC at the stenosis of the hepatic duct. The presence of ICC was confirmed at the lesion causing the stricture. The pathological diagnosis from the resected specimen was ICC based on PSC. Adjuvant chemotherapy for ICC was performed for 6 months. Neither cancer has recurred for 2.5 years after hepatectomy. Patients with PSC concomitant with UC should be considered a high-risk group for CAC and ICC.