Bath-PUVA therapy improves impaired resting regulatory T cells and increases activated regulatory T cells in psoriasis

Highlights • Psoriasis may be due to a regulatory T cell (Treg) imbalance. • Bath-psoralen plus ultraviolet light A (PUVA) therapy is effective for psoriasis. • Activated Treg, which suppress psoriatic activity, are increased by Bath-PUVA. • Resting Treg, which are low in psoriasis patients, are inc...

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Bibliographic Details
Published in:Journal of dermatological science 2017-04, Vol.86 (1), p.46-53
Main Authors: Kubo, Ryoji, Muramatsu, Shinnosuke, Sagawa, Yoko, Saito, Chiyo, Kasuya, Saori, Nishioka, Akiko, Nishida, Emi, Yamazaki, Sayuri, Morita, Akimichi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bath-PUVA therapy
Baths
Cytokines
Dermatology
Female
Forkhead Transcription Factors - metabolism
Humans
Male
Methoxsalen - administration & dosage
Methoxsalen - therapeutic use
Middle Aged
Photosensitizing Agents - administration & dosage
Photosensitizing Agents - therapeutic use
Psoriasis
Psoriasis - blood
Psoriasis - drug therapy
PUVA Therapy - methods
Regulatory
Severity of Illness Index
T-Lymphocytes
T-Lymphocytes, Regulatory - drug effects
T-Lymphocytes, Regulatory - metabolism
Treatment Outcome
Ultraviolet therapy
Young Adult
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Summary:Highlights • Psoriasis may be due to a regulatory T cell (Treg) imbalance. • Bath-psoralen plus ultraviolet light A (PUVA) therapy is effective for psoriasis. • Activated Treg, which suppress psoriatic activity, are increased by Bath-PUVA. • Resting Treg, which are low in psoriasis patients, are increased by Bath-PUVA. • Bath-PUVA may improve the Treg imbalance in psoriasis
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2017.01.001