BRI1/BAK1, a Receptor Kinase Pair Mediating Brassinosteroid Signaling

The Arabidopsis BAK1 ( BRI1 Associated receptor Kinase 1) was identified by a yeast two-hybrid screen as a specific interactor for BRI1, a critical component of a membrane brassinosteroid (BR) receptor. In yeast, BAK1/BRI1 interaction activates their kinase activities through transphosphorylation. B...

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Bibliographic Details
Published in:Cell 2002-07, Vol.110 (2), p.203-212
Main Authors: Nam, Kyoung Hee, Li, Jianming
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Arabidopsis
Arabidopsis Proteins
DNA, Bacterial
Enzyme Activation
Gene Expression
Genes, Plant
Hydroxysteroids - metabolism
Membrane Proteins - genetics
Membrane Proteins - metabolism
Molecular Sequence Data
Mutagenesis, Insertional
Phenotype
Protein Kinases - genetics
Protein Kinases - metabolism
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
Saccharomyces cerevisiae
Signal Transduction - physiology
Two-Hybrid System Techniques
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Summary:The Arabidopsis BAK1 ( BRI1 Associated receptor Kinase 1) was identified by a yeast two-hybrid screen as a specific interactor for BRI1, a critical component of a membrane brassinosteroid (BR) receptor. In yeast, BAK1/BRI1 interaction activates their kinase activities through transphosphorylation. BAK1 and BRI1 share similar gene expression and subcellular localization patterns and physically associate with each other in plants. Overexpression of the BAK1 gene leads to a phenotype reminiscent of BRI1-overexpression transgenic plants and rescues a weak bri1 mutant. In contrast, a bak1 knockout mutation gives rise to a weak bri1-like phenotype and enhances a weak bri1 mutation. We propose that BAK1 and BRI1 function together to mediate plant steroid signaling.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(02)00814-0