Osteoarticular and soft-tissue melioidosis in Malaysia: clinical characteristics and molecular typing of the causative agent

Melioidosis involving bone, joints, and soft tissue is rare and reported usually following dissemination of disease from infection elsewhere in the body; to a lesser degree, it can also be reported as the primary manifestation of melioidosis. The orthopedic registry at Hospital University Sains Mala...

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Bibliographic Details
Published in:Journal of infection in developing countries 2017-01, Vol.11 (1), p.28-33
Main Authors: Zueter, AbdelRahman Mohammad, Abumarzouq, Mahmoud, Yusof, Mohd Imran, Wan Ismail, Wan Faisham, Harun, Azian
Format: Article
Language:English
Subjects:
Adolescent
Adult
Burkholderia pseudomallei - classification
Burkholderia pseudomallei - genetics
Burkholderia pseudomallei - isolation & purification
Child
Diabetes Complications
Female
Humans
Malaysia - epidemiology
Male
Melioidosis - epidemiology
Melioidosis - microbiology
Melioidosis - pathology
Middle Aged
Molecular Typing
Osteoarthritis - epidemiology
Osteoarthritis - microbiology
Osteoarthritis - pathology
Retrospective Studies
Risk Factors
Soft Tissue Infections - epidemiology
Soft Tissue Infections - microbiology
Soft Tissue Infections - pathology
Survival Analysis
Young Adult
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Summary:Melioidosis involving bone, joints, and soft tissue is rare and reported usually following dissemination of disease from infection elsewhere in the body; to a lesser degree, it can also be reported as the primary manifestation of melioidosis. The orthopedic registry at Hospital University Sains Malaysia from 2008 until 2014 was retrospectively reviewed and was followed by molecular typing of Burkholderia pseudomallei. Out of 20 cases identified, 19 patients were confirmed to have osteoarticular and/or soft-tissue melioidosis. The majority of the patients were males (84%), and 16 patients had underlying diabetes mellitus with no significant estimated risk with the disease outcomes. Bacterial genotype was not associated with the disease as a risk. Death was a significant outcome in patients with bacteremic infections (p = 0.044). Patients with lung or skin melioidosis require careful treatment follow-up to minimize the chance for secondary osteoarticular infection. Human risk factors remain the leading predisposing factors for melioidosis. Early laboratory and clinical diagnosis and acute-phase treatment can decrease morbidity and mortality.
ISSN:1972-2680
2036-6590
1972-2680
DOI:10.3855/jidc.7612