Detection of bowel inflammation with fused DWI/T2 images versus contrast enhanced images in pediatric MR enterography with histopathologic correlation

Abstract Purpose To evaluate the fused, colorized DWI and anatomic T2 images compared to routine contrast-enhanced T1 images at pediatric MR enterography. Methods Fused, colorized DWI/T2 images were created from patients with MRE and colonoscopy/biopsy. Radiologists noted inflammation in 5 bowel seg...

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Bibliographic Details
Published in:Clinical imaging 2016-11, Vol.40 (6), p.1135-1139
Main Authors: Ehman, Eric C, Phelps, Andrew S, Ohliger, Michael A, Rhee, Sue J, MacKenzie, John D, Courtier, Jesse L
Format: Article
Language:English
Subjects:
Adolescent
Adults
Anesthesia
Biopsy
Child
Colitis - diagnosis
Colon
Colonoscopy
Contrast agents
Contrast Media
Diffusion Magnetic Resonance Imaging - methods
Diffusion-weighted imaging
Enterography
Female
Humans
Ileitis - diagnosis
Ileum
Image contrast
Image detection
Image Enhancement
Imaging
Inflammation
Inflammatory bowel disease
Intestine
Irritable Bowel Syndrome - diagnosis
Magnetic resonance
Magnetic resonance imaging
Male
Mathematical analysis
MRI
Observer Variation
Patients
Pediatric
Pediatrics
Proctocolitis - diagnosis
Radiology
Reproducibility of Results
Resonance
Retrospective Studies
Sensitivity
Sensitivity and Specificity
Studies
Terminals
Young Adult
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Summary:Abstract Purpose To evaluate the fused, colorized DWI and anatomic T2 images compared to routine contrast-enhanced T1 images at pediatric MR enterography. Methods Fused, colorized DWI/T2 images were created from patients with MRE and colonoscopy/biopsy. Radiologists noted inflammation in 5 bowel segments (terminal ileum-rectosigmoid colon) on post-contrast images and DWI/T2 images. Test characteristics and agreement were calculated. Results For 20 patients, sensitivity/specificity/PPV/NPV were 0.53/0.90/0.77/0.76 for DWI/T2 and 0.45/0.90/0.72/0.73 for post-contrast images. Intra-observer agreement was ҡ=0.45–0.73. Inter-observer agreement was ҡ=0.53 for DWI/T2 and ҡ=0.63 for post-contrast images. Conclusion DWI/T2 images are similar in sensitivity/specificity to contrast-enhanced images and with moderate intra/inter-observer reliability.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2016.07.006