Understanding osteomyelitis and its treatment through local drug delivery system

Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics is not an effective way to control the malaise due to so many reasons. Determination of optimal treatment strategy becomes difficult for the orthopaedic surgeons and as a consequence, the patients suffer not...

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Bibliographic Details
Published in:Biotechnology advances 2016-12, Vol.34 (8), p.1305-1317
Main Authors: Nandi, Samit Kumar, Bandyopadhyay, Samiran, Das, Piyali, Samanta, Indranil, Mukherjee, Prasenjit, Roy, Subhasis, Kundu, Biswanath
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Antibiotics
Biocompatibility
Biocompatible Materials
Biomedical materials
Bone diseases
Bones
Chromium
Drug Delivery Systems
Etiology
Experiments
Failure
Humans
Osteomyelitis - drug therapy
Osteomyelitis - epidemiology
Osteomyelitis - physiopathology
Risk Factors
Side effects
Toxicity
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Summary:Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics is not an effective way to control the malaise due to so many reasons. Determination of optimal treatment strategy becomes difficult for the orthopaedic surgeons and as a consequence, the patients suffer not only from therapeutic failure but also due to adverse side effects of antibiotics and financial loss due to additional stay at hospitals. A wide application of carrier systems, as a medium for local delivery of antibiotics, is being used experimentally and clinically for the treatment of osteomyelitis. This kind of delivery system provides sustained higher concentration of antibiotics at the infection site with reduced possibility of toxicity. This review highlight etiology and pathophysiology of osteomyelitis, current therapeutic options with their limitations, and potentiality of biomaterial based carrier materials impregnated with antibiotics as local delivery approach.
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2016.09.005