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Near-Infrared-Triggered Azobenzene-Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance

Overcoming multidrug resistance is achieved by developing a novel drugdelivery-system paradigm based on azobenzene liposome and phosphatidylcholine-modified upconversion nanoparticle (UCNP) hybrid vesicles for controlled drug release using a nearinfrared (NIR) laser. Upon 980 nm light irradiation, t...

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Published in:Advanced materials (Weinheim) 2016-11, Vol.28 (42), p.9341-9348
Main Authors: Yao, Chi, Wang, Peiyuan, Li, Xiaomin, Hu, Xiaoyu, Hou, Junli, Wang, Leyong, Zhang, Fan
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Language:English
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cited_by cdi_FETCH-LOGICAL-c432t-8875b3b30d3c93f723c6b92b45faa5e735471d0750db5cf235b7a93dc386e1333
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creator Yao, Chi
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description Overcoming multidrug resistance is achieved by developing a novel drugdelivery-system paradigm based on azobenzene liposome and phosphatidylcholine-modified upconversion nanoparticle (UCNP) hybrid vesicles for controlled drug release using a nearinfrared (NIR) laser. Upon 980 nm light irradiation, the reversible photoisomerization of the azobenzene derivatives by simultaneous UV and visible light emitted from the UCNPs makes it possible to realize NIR-triggered release of the chemotherapeutic drug doxorubicin.
doi_str_mv 10.1002/adma.201503799
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source Wiley-Blackwell Read & Publish Collection
subjects azobenzene-liposomes
Derivatives
drug delivery
Drug delivery systems
Lasers
Light irradiation
multidrug-resistant cancers
Nanostructure
Remote control
Upconversion
upconversion nanoparticles
Vesicles
title Near-Infrared-Triggered Azobenzene-Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance
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