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Near-Infrared-Triggered Azobenzene-Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance
Overcoming multidrug resistance is achieved by developing a novel drugdelivery-system paradigm based on azobenzene liposome and phosphatidylcholine-modified upconversion nanoparticle (UCNP) hybrid vesicles for controlled drug release using a nearinfrared (NIR) laser. Upon 980 nm light irradiation, t...
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Published in: | Advanced materials (Weinheim) 2016-11, Vol.28 (42), p.9341-9348 |
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Main Authors: | , , , , , , |
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container_end_page | 9348 |
container_issue | 42 |
container_start_page | 9341 |
container_title | Advanced materials (Weinheim) |
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creator | Yao, Chi Wang, Peiyuan Li, Xiaomin Hu, Xiaoyu Hou, Junli Wang, Leyong Zhang, Fan |
description | Overcoming multidrug resistance is achieved by developing a novel drugdelivery-system paradigm based on azobenzene liposome and phosphatidylcholine-modified upconversion nanoparticle (UCNP) hybrid vesicles for controlled drug release using a nearinfrared (NIR) laser. Upon 980 nm light irradiation, the reversible photoisomerization of the azobenzene derivatives by simultaneous UV and visible light emitted from the UCNPs makes it possible to realize NIR-triggered release of the chemotherapeutic drug doxorubicin. |
doi_str_mv | 10.1002/adma.201503799 |
format | article |
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source | Wiley-Blackwell Read & Publish Collection |
subjects | azobenzene-liposomes Derivatives drug delivery Drug delivery systems Lasers Light irradiation multidrug-resistant cancers Nanostructure Remote control Upconversion upconversion nanoparticles Vesicles |
title | Near-Infrared-Triggered Azobenzene-Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance |
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