Catalyst-free direct C–H trifluoromethylation of arenes in water–acetonitrile

We describe a mild and practical strategy for the catalyst-free trifluoromethylation of arenes using the inexpensive solid sodium triflinate (Langlois' reagent, NaSO2CF3) as a trifluoromethyl (CF3) source and solid sodium persulfate as an initiator. The reaction is environmentally friendly and...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2016-01, Vol.18 (22), p.5967-5970
Main Authors: Wang, Dangui, Deng, Guo-Jun, Chen, Shiya, Gong, Hang
Format: Article
Language:English
Subjects:
Aromatic compounds
Catalysts
Initiators
Organic chemistry
Reagents
Sodium
Strategy
Transformations
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Summary:We describe a mild and practical strategy for the catalyst-free trifluoromethylation of arenes using the inexpensive solid sodium triflinate (Langlois' reagent, NaSO2CF3) as a trifluoromethyl (CF3) source and solid sodium persulfate as an initiator. The reaction is environmentally friendly and proceeds at 30 degree C in a water-acetonitrile mixture. This transformation can be easily scaled up to the gram level with excellent yield.
ISSN:1463-9262
1463-9270
DOI:10.1039/c6gc02000c