Palladium-mediated in situ synthesis of an anticancer agent

As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (99), p.14212-14214
Main Authors: Indrigo, Eugenio, Clavadetscher, Jessica, Chankeshwara, Sunay V, Lilienkampf, Annamaria, Bradley, Mark
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biotechnology
Cell death
Cell Survival - drug effects
Chemical compounds
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Drugs
Humans
Metal Nanoparticles - chemistry
Molecular Structure
Nanoparticles
Palladium - chemistry
Particle Size
Precursors
Pyrazoles - chemical synthesis
Pyrazoles - chemistry
Pyrazoles - pharmacology
Pyrimidines - chemical synthesis
Pyrimidines - chemistry
Pyrimidines - pharmacology
Strategy
Structure-Activity Relationship
Surface Properties
Tumor Cells, Cultured
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Description
Summary:As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc08666g