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Gold(I)-Catalysed Cyclisation of Alkynoic Acids: Towards an Efficient and Eco-Friendly Synthesis of gamma -, delta - and -Lactones

The improved synthesis of gamma -, delta - and -lactones using a dinuclear N-heterocyclic carbene (NHC)-gold(I) catalyst is reported. This solvent-free process provides access to gamma - and delta -lactones in high regio- and stereoselectivity. Reactions were performed at low catalyst loadings and w...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2016-12, Vol.358 (23), p.3857-3862
Main Authors: Gasperini, Danila, Maggi, Lorenzo, Dupuy, Stephanie, Veenboer, Richard MP, Cordes, David B, Slawin, Alexandra MZ, Nolan, Steven P
Format: Article
Language:English
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Summary:The improved synthesis of gamma -, delta - and -lactones using a dinuclear N-heterocyclic carbene (NHC)-gold(I) catalyst is reported. This solvent-free process provides access to gamma - and delta -lactones in high regio- and stereoselectivity. Reactions were performed at low catalyst loadings and without the need for any additives. The use of a digold pre-catalyst provides a new synthetic route to functionalised -lactones, poorly accessible using previous methodologies.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600575