Loading…
Gold(I)-Catalysed Cyclisation of Alkynoic Acids: Towards an Efficient and Eco-Friendly Synthesis of gamma -, delta - and -Lactones
The improved synthesis of gamma -, delta - and -lactones using a dinuclear N-heterocyclic carbene (NHC)-gold(I) catalyst is reported. This solvent-free process provides access to gamma - and delta -lactones in high regio- and stereoselectivity. Reactions were performed at low catalyst loadings and w...
Saved in:
Published in: | Advanced synthesis & catalysis 2016-12, Vol.358 (23), p.3857-3862 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The improved synthesis of gamma -, delta - and -lactones using a dinuclear N-heterocyclic carbene (NHC)-gold(I) catalyst is reported. This solvent-free process provides access to gamma - and delta -lactones in high regio- and stereoselectivity. Reactions were performed at low catalyst loadings and without the need for any additives. The use of a digold pre-catalyst provides a new synthetic route to functionalised -lactones, poorly accessible using previous methodologies. |
---|---|
ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.201600575 |