Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation?

Abstract Objective To identify a shear wave speed (SWS) cutoff in pediatric liver disease to detect fibrosis and inflammation. Methods IRB-approved prospective study of liver SWS in 41 children undergoing liver biopsy. Results In patients without inflammation, SWS was higher when fibrosis was presen...

Full description

Saved in:
Bibliographic Details
Published in:Clinical imaging 2017-01, Vol.41, p.95-100
Main Authors: Phelps, Andrew, Ramachandran, Raga, Courtier, Jesse, Perito, Emily, Rosenthal, Philip, MacKenzie, John D
Format: Article
Language:English
Subjects:
Adolescent
Adult
ARFI
Child
Child, Preschool
Children
Elasticity Imaging Techniques - methods
Elastography
FDA approval
Female
Fibrosis
Gangrene
Gastroenterology
Histology
Humans
Imaging
Infant
Inflammation
Inflammation - diagnostic imaging
Inflammation - pathology
Liver
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver diseases
Liver Diseases - diagnostic imaging
Liver Diseases - pathology
Male
Pathology
Patients
Pediatrics
Prospective Studies
pSWE
Radiology
Screening
Shear wave speed
Sound waves
Studies
Ultrasonic imaging
Ultrasound
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objective To identify a shear wave speed (SWS) cutoff in pediatric liver disease to detect fibrosis and inflammation. Methods IRB-approved prospective study of liver SWS in 41 children undergoing liver biopsy. Results In patients without inflammation, SWS was higher when fibrosis was present compared to when fibrosis was not present (average SWS 1.8 versus 1.4 m/s, respectively, P =.02). A SWS cutoff of 1.7 m/s had 100% positive predictive value and 24% negative predictive value for detecting fibrosis or inflammation. Conclusion Point shear wave elastography is an insufficient stand-alone screening tool for liver fibrosis and inflammation in a heterogeneous patient population.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2016.10.012