Modular supramolecular ureidopyrimidinone polymer carriers for intracellular delivery

Ureidopyrimidinone-based polymers in solution provide a new platform for intracellular drug delivery. Here we show the synthesis of functional supramolecular polymers by mixing of monomers with various functionalities. Introduction of cationic monomers made them suitable for cellular uptake and siRN...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (112), p.110600-110603
Main Authors: Bakker, Maarten H., Kieltyka, Roxanne E., Albertazzi, Lorenzo, Dankers, Patricia Y. W.
Format: Article
Language:English
Subjects:
Carriers
Cationic
Drug delivery systems
Monomers
Platforms
Supramolecular polymers
Synthesis (chemistry)
Uptakes
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Summary:Ureidopyrimidinone-based polymers in solution provide a new platform for intracellular drug delivery. Here we show the synthesis of functional supramolecular polymers by mixing of monomers with various functionalities. Introduction of cationic monomers made them suitable for cellular uptake and siRNA delivery.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA22490C