Osteotropic peptide-mediated bone targeting for photothermal treatment of bone tumors

Abstract The treatment of bone tumors is a challenging problem due to the inefficient delivery of therapeutics to bone and the bone microenvironment-associated tumor resistance to chemo-and radiotherapy. Here, we developed a bone-targeted nanoparticle, aspartate octapeptide-modified dendritic platin...

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Bibliographic Details
Published in:Biomaterials 2017-01, Vol.114, p.97-105
Main Authors: Wang, Yitong, Yang, Jian, Liu, Hongmei, Wang, Xinyu, Zhou, Zhengjie, Huang, Quan, Song, Dianwen, Cai, Xiaopan, Li, Lin, Lin, Kaili, Xiao, Jianru, Liu, Peifeng, Zhang, Qiang, Cheng, Yiyun
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Biocompatibility
Biomedical materials
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Bone Neoplasms - therapy
Bone targeting
Bone tumor
Bones
Cell Line, Tumor
Dentistry
Fragments
Hyperthermia, Induced - methods
Male
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - therapeutic use
Mice
Mice, Inbred BALB C
Mice, Nude
Molecular Targeted Therapy - methods
Nanocapsules - administration & dosage
Nanocapsules - therapeutic use
Nanostructure
Oligopeptides - administration & dosage
Oligopeptides - pharmacokinetics
Osteoclastic bone resorption
Phototherapy - methods
Photothermal therapy
Platinum base alloys
Surgical implants
Treatment Outcome
Tumors
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Summary:Abstract The treatment of bone tumors is a challenging problem due to the inefficient delivery of therapeutics to bone and the bone microenvironment-associated tumor resistance to chemo-and radiotherapy. Here, we developed a bone-targeted nanoparticle, aspartate octapeptide-modified dendritic platinum-copper alloy nanoparticle (Asp-DPCN), for photothermal therapy (PTT) of bone tumors. Asp-DPCN showed much higher affinities toward hydroxyapatite and bone fragments than the non-targeted DPCN in vitro . Furthermore, Asp-DPCN accumulated more efficiently around bone tumors in vivo , and resulted in a higher temperature in bone tumors during PTT. Finally, Asp-DPCN-mediated PTT not only efficiently depressed the tumor growth but also significantly reduced the osteoclastic bone destruction. Our study developed a promising therapeutic approach for the treatment of bone tumors.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2016.11.010