Mechanisms and dose–response relationships for radiation-induced cardiovascular disease

Epidemiological studies have shown a clear association between therapeutic doses of thoracic irradiation and increased risk of cardiovascular disease in long-term cancer survivors. Survivors of Hodgkin’s lymphoma and childhood cancers, for example, show 2- to >7-fold increases in risk of cardiac...

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Bibliographic Details
Published in:Annals of the ICRP 2012-10, Vol.41 (3-4), p.72-79
Main Author: Stewart, F.A.
Format: Article
Language:English
Subjects:
Animals
Arteries
Atherosclerosis
Atherosclerosis - epidemiology
Atherosclerosis - etiology
Breast Neoplasms - radiotherapy
Cancer
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Dose-Response Relationship, Radiation
Endothelial cells
Endothelial Cells - radiation effects
Female
Heart
Heart - radiation effects
Heart diseases
Hodgkin Disease - radiotherapy
Humans
Inflammation
Male
Mice
Microvasculature damage
Myocardium - pathology
Neoplasms - radiotherapy
Radiotherapy - adverse effects
Rats
Risk
Thrombosis
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Summary:Epidemiological studies have shown a clear association between therapeutic doses of thoracic irradiation and increased risk of cardiovascular disease in long-term cancer survivors. Survivors of Hodgkin’s lymphoma and childhood cancers, for example, show 2- to >7-fold increases in risk of cardiac death after total tumour doses of 30–40Gy, given in 2-Gy fractions. The risk of cardiac mortality increases linearly with dose, although there are large uncertainties for mean cardiac doses
ISSN:0146-6453
1872-969X
DOI:10.1016/j.icrp.2012.06.031