Chlorhexidine Adsorption in Hydroxyapatite and Alginate Microspheres by Extrusion in Zinc and Calcium Chloride

In this work, the adsorption of a low-concentration solution of chlorhexidine (CHX), an antimicrobial drug, in hydroxyapatite (HA) and alginate microspheres was studied. The microspheres were formed by extrusion of a 1:10 mixture of alginate and HA in two different divalent solutions: CaCl2 and ZnCl...

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Published in:Key engineering materials 2016-11, Vol.720, p.25-30
Main Authors: Costa, Andrea Machado, Navarro da Rocha, Daniel, Ayad, Nadia Mohammed Elmassalami, Prado da Silva, Marcelo Henrique
Format: Article
Language:English
Subjects:
Adsorption
Alginates
Antimicrobial agents
Calcium chloride
Cell growth
Chlorhexidine
Chloride
Drug delivery systems
Extrusion
Hydroxyapatite
Microspheres
Microstructure
Scanning electron microscopy
Spectrum analysis
Zinc
Zinc oxides
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Navarro da Rocha, Daniel
Ayad, Nadia Mohammed Elmassalami
Prado da Silva, Marcelo Henrique
description In this work, the adsorption of a low-concentration solution of chlorhexidine (CHX), an antimicrobial drug, in hydroxyapatite (HA) and alginate microspheres was studied. The microspheres were formed by extrusion of a 1:10 mixture of alginate and HA in two different divalent solutions: CaCl2 and ZnCl2. UV-Vis spectroscopy showed that the microspheres adsorbed approximately half of the chlorhexidine in solution, which was initially at 0.2%. XRD patterns obtained prior adsorption confirmed the presence of HA as the only crystalline phase. Scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) analysis were performed before and after CHX adsorption. The spheres produced in CaCl2 solution did not show significant change after adsorption. However, samples obtained in ZnCl2 solution showed a different microstructure, with the presence of crystals with a high Zn concentration. X-Ray Fluorescence (XRF) confirmed the presence of ZnO in the samples after CHX absorption.
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subjects Adsorption
Alginates
Antimicrobial agents
Calcium chloride
Cell growth
Chlorhexidine
Chloride
Drug delivery systems
Extrusion
Hydroxyapatite
Microspheres
Microstructure
Scanning electron microscopy
Spectrum analysis
Zinc
Zinc oxides
title Chlorhexidine Adsorption in Hydroxyapatite and Alginate Microspheres by Extrusion in Zinc and Calcium Chloride
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