Differential effects of the 5-HT2 receptor antagonist on the anti-immobility effects of noradrenaline and serotonin reuptake inhibitors in the forced swimming test

The effects of the 5-HT(2) receptor antagonist, LY 53857 on the effects of noradrenaline and serotonin reuptake inhibitors were investigated using the forced swimming test. LY 53857 enhanced anti-immobility effects of clomipramine and maprotiline, which can inhibit reuptake of noradrenaline. However...

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Bibliographic Details
Published in:Brain research 2002-12, Vol.958 (1), p.161-165
Main Authors: YAMADA, Jun, SUGIMOTO, Yumi
Format: Article
Language:English
Subjects:
Adrenergic Uptake Inhibitors - pharmacology
Animals
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Brain - physiopathology
Clomipramine - pharmacology
Depressive Disorder - drug therapy
Depressive Disorder - metabolism
Depressive Disorder - physiopathology
Dose-Response Relationship, Drug
Drug Interactions - physiology
Ergolines - pharmacology
Fluoxetine - pharmacology
Fluvoxamine - pharmacology
Male
Maprotiline - pharmacology
Medical sciences
Mice
Miscellaneous
Motor Activity - drug effects
Motor Activity - physiology
Neurons - drug effects
Neurons - metabolism
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Norepinephrine - pharmacology
Pharmacology. Drug treatments
Receptors, Serotonin - drug effects
Receptors, Serotonin - metabolism
Serotonin - metabolism
Serotonin Antagonists - pharmacology
Serotonin Uptake Inhibitors - pharmacology
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
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Summary:The effects of the 5-HT(2) receptor antagonist, LY 53857 on the effects of noradrenaline and serotonin reuptake inhibitors were investigated using the forced swimming test. LY 53857 enhanced anti-immobility effects of clomipramine and maprotiline, which can inhibit reuptake of noradrenaline. However, LY 53857 did not affect the immobility time of mice treated with the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine. These results suggest that antagonism of the 5-HT(2) receptor leads to potentiation of the antidepressant effects of noradrenaline reuptake inhibitors but not SSRIs and that LY 53857 may modify the activity of noradrenergic neurons.
ISSN:0006-8993
1872-6240
DOI:10.1016/s0006-8993(02)03684-3