Utility of computed diffusion‐weighted MRI for predicting aggressiveness of prostate cancer

Purpose To investigate the value of computed (c) diffusion‐weighted imaging (DWI) in assessing prostate cancer aggressiveness. Materials and Methods Fifty‐five patients with peripheral zone prostate cancer who underwent prebiopsy 1.5T magnetic resonance imaging (including native DWI at b‐values of 0...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2017-08, Vol.46 (2), p.490-496
Main Authors: Waseda, Yuma, Yoshida, Soichiro, Takahara, Taro, Kwee, Thomas Christian, Matsuoka, Yoh, Saito, Kazutaka, Kihara, Kazunori, Fujii, Yasuhisa
Format: Article
Language:English
Subjects:
Aged
Area Under Curve
biomarkers
Cancer
Computation
Diffusion coefficient
Diffusion Magnetic Resonance Imaging
Gleason grading
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
multimodal imaging
Multivariate Analysis
Neoplasm Grading
Neoplasm Invasiveness
NMR
Nuclear magnetic resonance
Prostate cancer
Prostate-Specific Antigen - blood
Prostatectomy
prostatic neoplasms
Prostatic Neoplasms - diagnostic imaging
Quality
Reproducibility of Results
Retrospective Studies
ROC Curve
Sensitivity and Specificity
Signal Processing, Computer-Assisted
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Summary:Purpose To investigate the value of computed (c) diffusion‐weighted imaging (DWI) in assessing prostate cancer aggressiveness. Materials and Methods Fifty‐five patients with peripheral zone prostate cancer who underwent prebiopsy 1.5T magnetic resonance imaging (including native DWI at b‐values of 0 and 1000 s/mm2) were included. cDWI signal intensities of peripheral zone prostate cancer and nonmalignant prostate tissue were measured. Association between changes in monoexponentially calculated cDWI signals according to different b‐values and primary Gleason grades were assessed. Results The cDWI signal intensity of prostate cancer was lower at b = 0 s/mm2 and higher at b = 1000 s/mm2 compared to nonmalignant prostate tissue. The b‐value at which the signal intensities of prostate cancer and nonmalignant prostate tissue were equal was defined as the “iso‐b‐value.” On multivariate analysis, only the iso‐b‐value was a significant predictor of primary Gleason grade 4/5 cancer (P = 0.001). The area under the curve (AUC) of the iso‐b‐value for diagnosing primary Gleason grade 4/5 cancer was 0.94, and significantly higher than that of the tumor apparent diffusion coefficient (ADC) value with an AUC of 0.68 (P 
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.25593