Histological changes in the umbilical artery following severe chorioamnionitis and funisitis may be indicative of early atherosclerosis

Abstract We investigated whether histological evidence of early atherosclerosis was present in the umbilical artery of 21 pregnancies complicated by severe perinatal inflammation, and 21 controls matched for gestational age, sex and birth weight. Severe chorioamnionitis with funisitis was associated...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2017-02, Vol.50, p.40-43
Main Authors: Rafferty, Anthony R, D'Arcy, Colleen, Cann, Leonie, Pyman, Jan, Rogers, Peter, Davis, Peter G, Nowell, Cameron, Burgner, David
Format: Article
Language:English
Subjects:
Actins - metabolism
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Atherosclerosis
Atherosclerosis - metabolism
Atherosclerosis - pathology
Chorioamnionitis
Chorioamnionitis - metabolism
Chorioamnionitis - pathology
Down-Regulation
Female
Funisitis
Histopathology
Humans
Infant, Newborn
Internal Medicine
Intima-media thickness
Leukocyte Common Antigens - metabolism
Macrophages - metabolism
Macrophages - pathology
Obstetrics and Gynecology
Pregnancy
Umbilical Arteries - metabolism
Umbilical Arteries - pathology
Umbilical artery
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Summary:Abstract We investigated whether histological evidence of early atherosclerosis was present in the umbilical artery of 21 pregnancies complicated by severe perinatal inflammation, and 21 controls matched for gestational age, sex and birth weight. Severe chorioamnionitis with funisitis was associated with increased numbers of CD68 and CD45 positive cells (both P  
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2016.12.021