Serum Anti-Müllerian Hormone and Inhibin B as Potential Markers for Progressive Central Precocious Puberty in Girls

Abstract Study Objective To investigate the potential of serum anti-Müllerian hormone (AMH) and inhibin B (INHB) levels as markers for pubertal progression rate in girls with central precocious puberty (CPP). Design, Setting, Participants, Interventions, and Main Outcome Measures A total of 148 girl...

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Published in:Journal of pediatric & adolescent gynecology 2017-06, Vol.30 (3), p.362-366
Main Authors: Chen, Ting, MD, Wu, Haiying, MD, Xie, Rongrong, MD, Wang, Fengyun, MD, Chen, Xiuli, MD, Sun, Hui, MD, Chen, Linqi, MD
Format: Article
Language:English
Subjects:
Anti-Mullerian Hormone - blood
Anti-Müllerian hormone
Biomarkers - blood
Central precocious puberty
Child
Child, Preschool
Disease Progression
Female
Follow-Up Studies
Humans
Inhibin B
Inhibins - blood
Obstetrics and Gynecology
Pediatrics
Puberty, Precocious - blood
ROC Curve
Sensitivity and Specificity
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Summary:Abstract Study Objective To investigate the potential of serum anti-Müllerian hormone (AMH) and inhibin B (INHB) levels as markers for pubertal progression rate in girls with central precocious puberty (CPP). Design, Setting, Participants, Interventions, and Main Outcome Measures A total of 148 girls were enrolled, including 65 girls with premature thelarche and 83 girls with CPP, grouped on the basis of the results of gonadotropin-releasing hormone stimulation tests. Girls with CPP underwent a 6-month follow-up, and were further divided into 2 subgroups: the progressive CPP (P-CPP) group (n = 55) and the slowly P-CPP (SP-CPP) group (n = 28). Serum AMH and INHB levels were assessed in all enrolled girls. Using receiver operating characteristic curves, we analyzed the diagnostic performance of AMH and INHB to differentiate the 2 forms of CPP. Results Our data showed that AMH and INHB offer the potential to act as markers that distinguish SP-CPP from P-CPP. Compared with the SP-CPP group, girls with P-CPP showed lower AMH levels and higher INHB levels. On the basis of the receiver operating characteristics analysis, the area under the curve was 0.92 for the combination of AMH and INHB, with 80% sensitivity and 89.3% specificity. Conclusion Our results suggest that serum AMH and INHB levels provide a promising method in differentiating SP-CPP from P-CPP.
ISSN:1083-3188
1873-4332
DOI:10.1016/j.jpag.2017.01.010