Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus

Highlights • Iptakalim normalizes stress-induced depressive behaviour of mice. • Iptakalim normalizes stress-induced HPA axis disorder of mice. • Iptakalim alleviates inflammation in mouse hypothalamus. • Iptakalim alleviates oxidative stress in mouse hypothalamus.

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Bibliographic Details
Published in:Brain research bulletin 2017-04, Vol.130, p.146-155
Main Authors: Zhao, Xiao-Jie, Zhao, Zhan, Yang, Dan-Dan, Cao, Lu-Lu, Zhang, Ling, Ji, Juan, Gu, Jun, Huang, Ji-Ye, Sun, Xiu-Lan
Format: Article
Language:English
Subjects:
Animals
ATP-sensitive potassium channel
Depression - drug therapy
Depression - metabolism
Depression - prevention & control
Encephalitis - drug therapy
Encephalitis - metabolism
Encephalitis - prevention & control
HPA axis
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - metabolism
Inflammation
Iptakalim
KATP Channels - agonists
KATP Channels - metabolism
Male
Mice, Inbred C57BL
Mood disorders
Neurology
Oxidative stress
Oxidative Stress - drug effects
Pituitary-Adrenal System - drug effects
Pituitary-Adrenal System - metabolism
Propylamines - administration & dosage
Stress, Psychological
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Summary:Highlights • Iptakalim normalizes stress-induced depressive behaviour of mice. • Iptakalim normalizes stress-induced HPA axis disorder of mice. • Iptakalim alleviates inflammation in mouse hypothalamus. • Iptakalim alleviates oxidative stress in mouse hypothalamus.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2017.01.026