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Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus
Highlights • Iptakalim normalizes stress-induced depressive behaviour of mice. • Iptakalim normalizes stress-induced HPA axis disorder of mice. • Iptakalim alleviates inflammation in mouse hypothalamus. • Iptakalim alleviates oxidative stress in mouse hypothalamus.
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Published in: | Brain research bulletin 2017-04, Vol.130, p.146-155 |
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container_title | Brain research bulletin |
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creator | Zhao, Xiao-Jie Zhao, Zhan Yang, Dan-Dan Cao, Lu-Lu Zhang, Ling Ji, Juan Gu, Jun Huang, Ji-Ye Sun, Xiu-Lan |
description | Highlights • Iptakalim normalizes stress-induced depressive behaviour of mice. • Iptakalim normalizes stress-induced HPA axis disorder of mice. • Iptakalim alleviates inflammation in mouse hypothalamus. • Iptakalim alleviates oxidative stress in mouse hypothalamus. |
doi_str_mv | 10.1016/j.brainresbull.2017.01.026 |
format | article |
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subjects | Animals ATP-sensitive potassium channel Depression - drug therapy Depression - metabolism Depression - prevention & control Encephalitis - drug therapy Encephalitis - metabolism Encephalitis - prevention & control HPA axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Inflammation Iptakalim KATP Channels - agonists KATP Channels - metabolism Male Mice, Inbred C57BL Mood disorders Neurology Oxidative stress Oxidative Stress - drug effects Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Propylamines - administration & dosage Stress, Psychological |
title | Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus |
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