Loading…

Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus

Highlights • Iptakalim normalizes stress-induced depressive behaviour of mice. • Iptakalim normalizes stress-induced HPA axis disorder of mice. • Iptakalim alleviates inflammation in mouse hypothalamus. • Iptakalim alleviates oxidative stress in mouse hypothalamus.

Saved in:
Bibliographic Details
Published in:Brain research bulletin 2017-04, Vol.130, p.146-155
Main Authors: Zhao, Xiao-Jie, Zhao, Zhan, Yang, Dan-Dan, Cao, Lu-Lu, Zhang, Ling, Ji, Juan, Gu, Jun, Huang, Ji-Ye, Sun, Xiu-Lan
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c435t-2d965b57696b9d192f5c89ff719bc04bc44c38e47e7416399357f5de8a4dd3d43
cites cdi_FETCH-LOGICAL-c435t-2d965b57696b9d192f5c89ff719bc04bc44c38e47e7416399357f5de8a4dd3d43
container_end_page 155
container_issue
container_start_page 146
container_title Brain research bulletin
container_volume 130
creator Zhao, Xiao-Jie
Zhao, Zhan
Yang, Dan-Dan
Cao, Lu-Lu
Zhang, Ling
Ji, Juan
Gu, Jun
Huang, Ji-Ye
Sun, Xiu-Lan
description Highlights • Iptakalim normalizes stress-induced depressive behaviour of mice. • Iptakalim normalizes stress-induced HPA axis disorder of mice. • Iptakalim alleviates inflammation in mouse hypothalamus. • Iptakalim alleviates oxidative stress in mouse hypothalamus.
doi_str_mv 10.1016/j.brainresbull.2017.01.026
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1865519273</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0361923016304555</els_id><sourcerecordid>1865519273</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-2d965b57696b9d192f5c89ff719bc04bc44c38e47e7416399357f5de8a4dd3d43</originalsourceid><addsrcrecordid>eNqNks9u1DAQxiMEokvhFZDFiUsWO46dhAPSqvwpUiUqUc6WY09Ybx178SSrLg_Ic-GwBSFOnGxZv_nm83xTFC8YXTPK5Kvduk_ahQTYz96vK8qaNWVrWskHxYq1DS-rpm4eFivKJSu7itOz4gnijlIqWyEfF2dVyyRjnVgVPzZmcgc9uRhIHMjm5rpECOjyI5B9nDSim0ditjoE8KQ_Eref9K32biQhpjFfvgMSnLIbLF2wswFLLq83RN85JNZhTBYS0cESC_uFWpR72OqDi3NaFLX3cHDZQ_hKXBi8HseToaUo3jmrf7k59cgEGeOMQLbH7G-rMz7j0-LRoD3Cs_vzvPjy_t3NxWV59enDx4vNVWlqLqaysp0UvWhkJ_vOsq4ahGm7YWhY1xta96auDW-hbqCpmeRdx0UzCAutrq3ltubnxcuT7j7FbzPgpEaHBrzXAbIpxVopRNZteEZfn1CTImKCQe2TG3U6KkbVkqPaqb9zVEuOijKVc8zFz-_7zP0I9k_p7-Ay8PYEQP7twUFSaByEPHyXwEzKRvd_fd78I2O8C85ofwtHwF1OKOR5KqawUlR9XjZqWag8HFoLIfhP_ibRFw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1865519273</pqid></control><display><type>article</type><title>Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus</title><source>ScienceDirect Journals</source><creator>Zhao, Xiao-Jie ; Zhao, Zhan ; Yang, Dan-Dan ; Cao, Lu-Lu ; Zhang, Ling ; Ji, Juan ; Gu, Jun ; Huang, Ji-Ye ; Sun, Xiu-Lan</creator><creatorcontrib>Zhao, Xiao-Jie ; Zhao, Zhan ; Yang, Dan-Dan ; Cao, Lu-Lu ; Zhang, Ling ; Ji, Juan ; Gu, Jun ; Huang, Ji-Ye ; Sun, Xiu-Lan</creatorcontrib><description>Highlights • Iptakalim normalizes stress-induced depressive behaviour of mice. • Iptakalim normalizes stress-induced HPA axis disorder of mice. • Iptakalim alleviates inflammation in mouse hypothalamus. • Iptakalim alleviates oxidative stress in mouse hypothalamus.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/j.brainresbull.2017.01.026</identifier><identifier>PMID: 28161195</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; ATP-sensitive potassium channel ; Depression - drug therapy ; Depression - metabolism ; Depression - prevention &amp; control ; Encephalitis - drug therapy ; Encephalitis - metabolism ; Encephalitis - prevention &amp; control ; HPA axis ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - metabolism ; Inflammation ; Iptakalim ; KATP Channels - agonists ; KATP Channels - metabolism ; Male ; Mice, Inbred C57BL ; Mood disorders ; Neurology ; Oxidative stress ; Oxidative Stress - drug effects ; Pituitary-Adrenal System - drug effects ; Pituitary-Adrenal System - metabolism ; Propylamines - administration &amp; dosage ; Stress, Psychological</subject><ispartof>Brain research bulletin, 2017-04, Vol.130, p.146-155</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-2d965b57696b9d192f5c89ff719bc04bc44c38e47e7416399357f5de8a4dd3d43</citedby><cites>FETCH-LOGICAL-c435t-2d965b57696b9d192f5c89ff719bc04bc44c38e47e7416399357f5de8a4dd3d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28161195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Xiao-Jie</creatorcontrib><creatorcontrib>Zhao, Zhan</creatorcontrib><creatorcontrib>Yang, Dan-Dan</creatorcontrib><creatorcontrib>Cao, Lu-Lu</creatorcontrib><creatorcontrib>Zhang, Ling</creatorcontrib><creatorcontrib>Ji, Juan</creatorcontrib><creatorcontrib>Gu, Jun</creatorcontrib><creatorcontrib>Huang, Ji-Ye</creatorcontrib><creatorcontrib>Sun, Xiu-Lan</creatorcontrib><title>Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Highlights • Iptakalim normalizes stress-induced depressive behaviour of mice. • Iptakalim normalizes stress-induced HPA axis disorder of mice. • Iptakalim alleviates inflammation in mouse hypothalamus. • Iptakalim alleviates oxidative stress in mouse hypothalamus.</description><subject>Animals</subject><subject>ATP-sensitive potassium channel</subject><subject>Depression - drug therapy</subject><subject>Depression - metabolism</subject><subject>Depression - prevention &amp; control</subject><subject>Encephalitis - drug therapy</subject><subject>Encephalitis - metabolism</subject><subject>Encephalitis - prevention &amp; control</subject><subject>HPA axis</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Inflammation</subject><subject>Iptakalim</subject><subject>KATP Channels - agonists</subject><subject>KATP Channels - metabolism</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Mood disorders</subject><subject>Neurology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pituitary-Adrenal System - drug effects</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>Propylamines - administration &amp; dosage</subject><subject>Stress, Psychological</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNks9u1DAQxiMEokvhFZDFiUsWO46dhAPSqvwpUiUqUc6WY09Ybx178SSrLg_Ic-GwBSFOnGxZv_nm83xTFC8YXTPK5Kvduk_ahQTYz96vK8qaNWVrWskHxYq1DS-rpm4eFivKJSu7itOz4gnijlIqWyEfF2dVyyRjnVgVPzZmcgc9uRhIHMjm5rpECOjyI5B9nDSim0ditjoE8KQ_Eref9K32biQhpjFfvgMSnLIbLF2wswFLLq83RN85JNZhTBYS0cESC_uFWpR72OqDi3NaFLX3cHDZQ_hKXBi8HseToaUo3jmrf7k59cgEGeOMQLbH7G-rMz7j0-LRoD3Cs_vzvPjy_t3NxWV59enDx4vNVWlqLqaysp0UvWhkJ_vOsq4ahGm7YWhY1xta96auDW-hbqCpmeRdx0UzCAutrq3ltubnxcuT7j7FbzPgpEaHBrzXAbIpxVopRNZteEZfn1CTImKCQe2TG3U6KkbVkqPaqb9zVEuOijKVc8zFz-_7zP0I9k_p7-Ay8PYEQP7twUFSaByEPHyXwEzKRvd_fd78I2O8C85ofwtHwF1OKOR5KqawUlR9XjZqWag8HFoLIfhP_ibRFw</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Zhao, Xiao-Jie</creator><creator>Zhao, Zhan</creator><creator>Yang, Dan-Dan</creator><creator>Cao, Lu-Lu</creator><creator>Zhang, Ling</creator><creator>Ji, Juan</creator><creator>Gu, Jun</creator><creator>Huang, Ji-Ye</creator><creator>Sun, Xiu-Lan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus</title><author>Zhao, Xiao-Jie ; Zhao, Zhan ; Yang, Dan-Dan ; Cao, Lu-Lu ; Zhang, Ling ; Ji, Juan ; Gu, Jun ; Huang, Ji-Ye ; Sun, Xiu-Lan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-2d965b57696b9d192f5c89ff719bc04bc44c38e47e7416399357f5de8a4dd3d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>ATP-sensitive potassium channel</topic><topic>Depression - drug therapy</topic><topic>Depression - metabolism</topic><topic>Depression - prevention &amp; control</topic><topic>Encephalitis - drug therapy</topic><topic>Encephalitis - metabolism</topic><topic>Encephalitis - prevention &amp; control</topic><topic>HPA axis</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>Inflammation</topic><topic>Iptakalim</topic><topic>KATP Channels - agonists</topic><topic>KATP Channels - metabolism</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>Mood disorders</topic><topic>Neurology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pituitary-Adrenal System - drug effects</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>Propylamines - administration &amp; dosage</topic><topic>Stress, Psychological</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Xiao-Jie</creatorcontrib><creatorcontrib>Zhao, Zhan</creatorcontrib><creatorcontrib>Yang, Dan-Dan</creatorcontrib><creatorcontrib>Cao, Lu-Lu</creatorcontrib><creatorcontrib>Zhang, Ling</creatorcontrib><creatorcontrib>Ji, Juan</creatorcontrib><creatorcontrib>Gu, Jun</creatorcontrib><creatorcontrib>Huang, Ji-Ye</creatorcontrib><creatorcontrib>Sun, Xiu-Lan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Xiao-Jie</au><au>Zhao, Zhan</au><au>Yang, Dan-Dan</au><au>Cao, Lu-Lu</au><au>Zhang, Ling</au><au>Ji, Juan</au><au>Gu, Jun</au><au>Huang, Ji-Ye</au><au>Sun, Xiu-Lan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>130</volume><spage>146</spage><epage>155</epage><pages>146-155</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>Highlights • Iptakalim normalizes stress-induced depressive behaviour of mice. • Iptakalim normalizes stress-induced HPA axis disorder of mice. • Iptakalim alleviates inflammation in mouse hypothalamus. • Iptakalim alleviates oxidative stress in mouse hypothalamus.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28161195</pmid><doi>10.1016/j.brainresbull.2017.01.026</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0361-9230
ispartof Brain research bulletin, 2017-04, Vol.130, p.146-155
issn 0361-9230
1873-2747
language eng
recordid cdi_proquest_miscellaneous_1865519273
source ScienceDirect Journals
subjects Animals
ATP-sensitive potassium channel
Depression - drug therapy
Depression - metabolism
Depression - prevention & control
Encephalitis - drug therapy
Encephalitis - metabolism
Encephalitis - prevention & control
HPA axis
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - metabolism
Inflammation
Iptakalim
KATP Channels - agonists
KATP Channels - metabolism
Male
Mice, Inbred C57BL
Mood disorders
Neurology
Oxidative stress
Oxidative Stress - drug effects
Pituitary-Adrenal System - drug effects
Pituitary-Adrenal System - metabolism
Propylamines - administration & dosage
Stress, Psychological
title Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T02%3A00%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Activation%20of%20ATP-sensitive%20potassium%20channel%20by%20iptakalim%20normalizes%20stress-induced%20HPA%20axis%20disorder%20and%20depressive%20behaviour%20by%20alleviating%20inflammation%20and%20oxidative%20stress%20in%20mouse%20hypothalamus&rft.jtitle=Brain%20research%20bulletin&rft.au=Zhao,%20Xiao-Jie&rft.date=2017-04-01&rft.volume=130&rft.spage=146&rft.epage=155&rft.pages=146-155&rft.issn=0361-9230&rft.eissn=1873-2747&rft_id=info:doi/10.1016/j.brainresbull.2017.01.026&rft_dat=%3Cproquest_cross%3E1865519273%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c435t-2d965b57696b9d192f5c89ff719bc04bc44c38e47e7416399357f5de8a4dd3d43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1865519273&rft_id=info:pmid/28161195&rfr_iscdi=true