High frequency of the DRD2/ANKK1 A1 allele in Mexican Native Amerindians and Mestizos and its association with alcohol consumption

Highlights • Mexican populations have high frequencies of the DRD2 / ANNK1 A1 allele. • Native Amerindians have the highest prevalence of the DRD2/ANNK1 A1 allele globally. • The DRD2/ANKK1 A1A1 genotype is associated with heavy alcohol drinking in Mestizos. • A genetic background is involved in alc...

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Bibliographic Details
Published in:Drug and alcohol dependence 2017-03, Vol.172, p.66-72
Main Authors: Panduro, Arturo, Ramos-Lopez, Omar, Campollo, Octavio, Zepeda-Carrillo, Eloy Alfonso, Gonzalez-Aldaco, Karina, Torres-Valadez, Rafael, Roman, Sonia
Format: Article
Language:English
Subjects:
Adult
Alcohol
Alcohol consumption
Alcohol Drinking - genetics
Alcohol use
Alcoholism - epidemiology
Alcoholism - genetics
Alcohols
Alleles
Associations
Cross-Sectional Studies
Discrimination
Dopamine D2 receptor
Dopamine D2 receptors
DRD2/ANKK1
Drinking
Drinking behavior
Ethnic Groups
Female
Gene Frequency
Genotype
Genotypes
Genotyping
High frequencies
Hispanic Americans - statistics & numerical data
Humans
Indians, North American - statistics & numerical data
Liver Function Tests
Male
Mexico
Mexico - epidemiology
Middle Aged
Native Amerindians
Polymerase chain reaction
Polymorphism
Population genetics
Population studies
Populations
Protein-Serine-Threonine Kinases - genetics
Psychiatry
Receptors, Dopamine D2 - genetics
Restriction fragment length polymorphism
Sociocultural factors
United States - epidemiology
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Summary:Highlights • Mexican populations have high frequencies of the DRD2 / ANNK1 A1 allele. • Native Amerindians have the highest prevalence of the DRD2/ANNK1 A1 allele globally. • The DRD2/ANKK1 A1A1 genotype is associated with heavy alcohol drinking in Mestizos. • A genetic background is involved in alcohol consumption among Mexicans.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2016.12.006