Metformin‐SGLT2, Dehydration, and Acidosis Potential

Clinicians are aware of the risks and benefits of metformin in type 2 diabetes. In geriatric populations lactic acidosis due to diminishing kidney function is an issue. The recent addition of a group of agents to control diabetes through increased glycosuria may increase the risk of dehydration and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2017-05, Vol.65 (5), p.e101-e102
Main Authors: D'Elia, John A., Segal, Alissa R., Weinrauch, Larry A.
Format: Article
Language:English
Subjects:
acidosis
Acidosis, Lactic - etiology
Aged, 80 and over
dehydration
Dehydration - etiology
Diabetes Mellitus, Type 2 - drug therapy
Humans
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - therapeutic use
Male
metformin
Metformin - adverse effects
Metformin - therapeutic use
Risk Factors
SGLT‐2 inhibitors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Clinicians are aware of the risks and benefits of metformin in type 2 diabetes. In geriatric populations lactic acidosis due to diminishing kidney function is an issue. The recent addition of a group of agents to control diabetes through increased glycosuria may increase the risk of dehydration and acidosis. This may happen due to gastrointestinal loss from metformin diarrhea or urine loss from diuretics. A typical example is presented.
ISSN:0002-8614
1532-5415
DOI:10.1111/jgs.14724