A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested

Approximately, one-third of those who develop major depression will have a poor response to treatment and over time can become treatment resistant. Intestinal dysbiosis has been implicated in depression with systemic inflammation and vagal and enteric nerve impairment. We report on a sequel pilot st...

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Bibliographic Details
Published in:Inflammopharmacology 2017-04, Vol.25 (2), p.271-274
Main Authors: Bambling, Matthew, Edwards, Sophie C., Hall, Sean, Vitetta, Luis
Format: Article
Language:English
Subjects:
Adult
Allergology
Anti-Inflammatory Agents - administration & dosage
Antidepressive Agents - administration & dosage
Biomedical and Life Sciences
Biomedicine
Cohort Studies
Depressive Disorder, Treatment-Resistant - diagnosis
Depressive Disorder, Treatment-Resistant - drug therapy
Dermatology
Drug Therapy, Combination
Female
Follow-Up Studies
Gastroenterology
Gastrointestinal Tract - drug effects
Gastrointestinal Tract - microbiology
Gastrointestinal Tract - pathology
Humans
Immunology
Male
Middle Aged
Orotic Acid - administration & dosage
Orotic Acid - analogs & derivatives
Pharmacology/Toxicology
Pilot Projects
Probiotics - administration & dosage
Rheumatology
Serotonin Uptake Inhibitors - administration & dosage
Short Communication
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Summary:Approximately, one-third of those who develop major depression will have a poor response to treatment and over time can become treatment resistant. Intestinal dysbiosis has been implicated in depression with systemic inflammation and vagal and enteric nerve impairment. We report on a sequel pilot study ( n  = 12) with a combination probiotics/magnesium orotate formulation adjuvant administered with SSRIs for treatment resistant depression. At the end of an 8-week intervention mean changes for depression scores and quality of life in the group was clinically significantly improved ( p  
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-017-0311-x