Melanocortin Receptor-4 Gene Polymorphisms in Glioblastoma Patients Treated with Concomitant Radio-Chemotherapy

Melanocortins are peptides with well-recognized antiinflammatory and neuroprotective activity. No data are currently available on melanocortin receptor-4 ( MC4R ) gene polymorphisms and tumors, including glioblastomas (GBMs), or their relationship with radiotherapy or chemotherapy. The aim of this s...

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Bibliographic Details
Published in:Molecular neurobiology 2018-02, Vol.55 (2), p.1396-1404
Main Authors: Pasqualetti, Francesco, Orlandi, Paola, Simeon, Vittorio, Cantarella, Martina, Giuliani, Daniela, Di Desidero, Teresa, Gonnelli, Alessandra, Delishaj, Durim, Lombardi, Giuseppe, Sechi, Andrea, Sanson, Marc, Zagonel, Vittorina, Paiar, Fabiola, Danesi, Romano, Guarini, Salvatore, Bocci, Guido
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomedical and Life Sciences
Biomedicine
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - mortality
Brain Neoplasms - therapy
Cell Biology
Chemoradiotherapy
Chemotherapy
Clinical trials
Female
Genotype & phenotype
Genotypes
Genotyping
Glioblastoma
Glioblastoma - genetics
Glioblastoma - mortality
Glioblastoma - therapy
Humans
Male
Melanocortin
Melanocortin MC4 receptors
Middle Aged
Neurobiology
Neurology
Neuroprotection
Neurosciences
Peptides
Polymorphism
Polymorphism, Single Nucleotide
Prognosis
Radiation therapy
Receptor, Melanocortin, Type 4 - genetics
Retrospective Studies
Single-nucleotide polymorphism
Survival
Survival Rate
Temozolomide
Treatment Outcome
Tumors
Young Adult
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Summary:Melanocortins are peptides with well-recognized antiinflammatory and neuroprotective activity. No data are currently available on melanocortin receptor-4 ( MC4R ) gene polymorphisms and tumors, including glioblastomas (GBMs), or their relationship with radiotherapy or chemotherapy. The aim of this study was to evaluate the possible predictive/prognostic role of the MC4R SNPs on GBM patients. Fifty-five patients with a proven diagnosis of GBM, treated with radiotherapy and temozolomide, were consecutively enrolled. MC4R gene SNPs (rs17782313, rs489693, rs8087522, rs17700633) were analyzed by a validated TaqMan® SNP genotyping assays. Univariate and multivariate analyses were performed. A P  
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-017-0414-9