Increased plasma level of catestatin might be associated with poor prognosis in hemodialysis patients

Purpose Cardiac complication is a major cause of death in hemodialysis patients. The aim of the study was to determine the relationship between plasma catestatin level and cardiac death in those people. Methods A total of 330 maintenance hemodialysis patients were included. Blood samples were collec...

Full description

Saved in:
Bibliographic Details
Published in:International urology and nephrology 2017-06, Vol.49 (6), p.1063-1069
Main Authors: Sun, Huaibin, Xian, Wanhua, Geng, Lina, Li, Engang, Peng, Zhiguo, Tian, Jun
Format: Article
Language:English
Subjects:
Aged
Body Water
Body Weight
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - mortality
Chromogranin A - blood
Death
Diuresis
Enzyme-linked immunosorbent assay
Female
Follow-Up Studies
Heart diseases
Heart rate
Hemodialysis
Humans
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - therapy
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Nephrology - Original Paper
Organism Hydration Status
Patients
Peptide Fragments - blood
Plasma
Prognosis
Renal Dialysis
Survival analysis
Survival Rate
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Cardiac complication is a major cause of death in hemodialysis patients. The aim of the study was to determine the relationship between plasma catestatin level and cardiac death in those people. Methods A total of 330 maintenance hemodialysis patients were included. Blood samples were collected. Plasma catestatin level was detected by enzyme-linked immunosorbent assay. Fluid status of each patient was expressed by overhydration to total body weight ratio and daily diuresis. Each patient was followed-up for 36 months, unless some of them died in the follow-up period. Results In the follow-up period, only one hemodialysis patient was lost, 29 patients were died of cardiovascular diseases, 28 patients were died of other diseases and remaining 272 patients survived. Logistic multivariate regression analysis revealed that patients with plasma catestatin level ≥1.9 ng/ml were associated with increased cardiac death risk (RR 6.13, 95% CI 2.54, 18.45), and survival analysis also showed that cardiac death rate in patients with plasma catestatin level ≥1.9 ng/ml was elevated than that in patients with plasma catestatin level
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-017-1528-8