Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience

• Published in: The Pan African medical journal 2016, Vol.25, p.10-10
• Main Authors: Serragui, Samira, Zalagh, Fatima, Tanani, Driss Soussi, Ouammi, Lahcen, Moussa, Latifa Ait, Badrane, Narjis, Bencheikh, Rachida Soulaymani
• Format: Article
• Language: fre
• Subjects: Anticonvulsants - administration & dosage; Anticonvulsants - adverse effects; Anticonvulsants - therapeutic use; Carbamazepine - administration & dosage; Carbamazepine - adverse effects; Carbamazepine - therapeutic use; Dose-Response Relationship, Drug; Drug Monitoring - methods; Epilepsy - drug therapy; Humans; Medication Adherence; Morocco; Phenobarbital - administration & dosage; Phenobarbital - adverse effects; Phenobarbital - therapeutic use; Retrospective Studies; Valproic Acid - administration & dosage; Valproic Acid - adverse effects; Valproic Acid - therapeutic use
• ISSN: 1937-8688
• DOI: 10.11604/pamj.2016.25.10.9664

The therapeutic drug monitoring (TDM) of antiepileptic drugs is a tool widely used in the management of epilepsy. In Morocco, this monitoring is carried out by the Centre Anti Poison et Pharmacovigilance (CAPM) since April 1995. This is a retrospective study spanning 20 years. It concerns the therapeutic drug monitoring of Phenobarbital (PB) of carbamazepine (CBZ) and valproic acid (VPA). Therapeutic drug monitoring of the 3 antiepileptic drugs represent 58.85% of all applications received by the CAPM. The dosage of PB was ranked first followed by that of CBZ and finally by the VPA. Weak demand for therapeutic drug monitoring in Morocco could be explained by the low number of neurologists in addition to social factors. With its affordable price by patients, PB is the most prescribed antiepileptic drug in our country, which explains the high demand for its dosage. As for the therapeutic drug monitoring of the antiepileptic drug, they were mainly related to age, the occurrence of adverse effects, the association antiepileptic drugs or in the case of verification of patient compliance. Efforts are required for promoting the interests of therapeutic drug monitoring of antiepileptic drug in the management of epilepsy in Morocco.