Neuroendocrine liver metastasis: The chance to be cured after liver surgery

Background and Objective Neuroendocrine liver metastasis tumors (NELM) are a heterogeneous group of neoplasms with varied histologic features and a wide range of clinical behaviors. We aimed to identify the fraction of patients cured after liver surgery for NELM. Methods Cure fraction models were us...

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Bibliographic Details
Published in:Journal of surgical oncology 2017-05, Vol.115 (6), p.687-695
Main Authors: Bagante, Fabio, Spolverato, Gaya, Merath, Katiuscha, Postlewait, Lauren McLendon, Poultsides, George A., Mullen, Matthew G., Bauer, Todd W., Fields, Ryan C., Lamelas, Jorge, Marques, Hugo P., Aldrighetti, Luca, Tran, Thuy, Maithel, Shishir K., Pawlik, Timothy M.
Format: Article
Language:English
Subjects:
Aged
Cancer surgery
cure model
Disease-Free Survival
Female
Gastrointestinal Neoplasms - mortality
Gastrointestinal Neoplasms - pathology
Gastrointestinal Neoplasms - surgery
Humans
Liver
Liver Neoplasms - mortality
Liver Neoplasms - secondary
Liver Neoplasms - surgery
liver surgery
Male
Medical prognosis
Metastasis
Middle Aged
Models, Statistical
neuroendocrine liver metastasis
Neuroendocrine Tumors - mortality
Neuroendocrine Tumors - surgery
Proportional Hazards Models
Surgery
Survival Rate
United States - epidemiology
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Summary:Background and Objective Neuroendocrine liver metastasis tumors (NELM) are a heterogeneous group of neoplasms with varied histologic features and a wide range of clinical behaviors. We aimed to identify the fraction of patients cured after liver surgery for NELM. Methods Cure fraction models were used to analyze 376 patients who underwent hepatectomy with curative intent for NELM. Results The median and 5‐year disease‐free survival (DFS) were 4.5 years and 46%, respectively. The probability of being cured from NELM by liver surgery was 44%; the time to cure was 5.1 years. In a multivariable cure model, type of neuroendocrine tumor (NET), grade of tumor differentiation, and rate of liver involvement resulted as independent predictors of cure. The cure fraction for patients with well differentiated NELM from gastrointestinal NET or a functional pancreatic NET, and with 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.24563