Post-dexamethasone serum copeptin corresponds to HPA axis responsiveness in human obesity

Highlights • We compared obese, otherwise healthy subjects (OB) to matched non-obesity controls (NOC). • Serum copeptin, released from the same precursor as vasopressin, was higher in OB. • OB also had higher ACTH and cortisol output in the combined dexamethasone crh test. • This supports a role for...

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Published in:Psychoneuroendocrinology 2017-04, Vol.78, p.39-47
Main Authors: Schinke, Christian, Hesse, Swen, Stoppe, Muriel, Meyer, Klara, Schmidt, Elisa, Orthgiess, Johannes, Bechmann, Lukas, Bresch, Anke, Rullmann, Michael, Luthardt, Julia, Sabri, Osama, Blüher, Matthias, Kratzsch, Jürgen, Bergh, Florian Then
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Adult
Copeptin
Cross-Sectional Studies
Dexamethasone
Dexamethasone crh test
Endocrinology & Metabolism
Female
Glycopeptides - blood
HPA axis
Humans
Hydrocortisone - blood
Hypothalamo-Hypophyseal System - physiopathology
Male
Middle Aged
Neuroendocrinology
Obesity
Obesity - blood
Obesity - physiopathology
Pituitary-Adrenal Function Tests
Pituitary-Adrenal System - physiopathology
Psychiatry
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Summary:Highlights • We compared obese, otherwise healthy subjects (OB) to matched non-obesity controls (NOC). • Serum copeptin, released from the same precursor as vasopressin, was higher in OB. • OB also had higher ACTH and cortisol output in the combined dexamethasone crh test. • This supports a role for vasopressin co-stimulation in the pathophysiology of HPA axis hyperactivity.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2017.01.004