Leukocytoclastic Vasculitis Associated with Endocarditis in a Patient with Transposition of the Great Arteries and Mechanical Valve Replacement

Abstract Immunological vascular phenomena can be the initial manifestation of bacterial infection and endocarditis. Here, we report a rare case of leukocytoclastic vasculitis without immune complexes or cryoglobulinemia in a patient with infective endocarditis, congenital heart disease and a prior m...

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Bibliographic Details
Published in:Cardiovascular pathology 2017-03, Vol.27, p.68-70
Main Authors: Riehle, Christian, Scharf, Gesine M, Sieweke, Jan-Thorben, Zauner, Florian, Flierl, Ulrike, Treptau, Jens, Zormpas, Christos, Senf, Jana, McCarty, Nicholas S, Bauersachs, Johann, Sedding, Daniel G, Westhoff-Bleck, Mechthild
Format: Article
Language:English
Subjects:
Adult
Congenital heart disease
Endocarditis of a prosthetic valve
Endocarditis, Bacterial - complications
Female
Heart Valve Prosthesis
Humans
Leukocytoclastic vasculitis
Pathology
Postoperative Complications
Staphylococcal Infections - complications
Transposition of Great Vessels - complications
Transposition of the great arteries
Vasculitis, Leukocytoclastic, Cutaneous - etiology
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Summary:Abstract Immunological vascular phenomena can be the initial manifestation of bacterial infection and endocarditis. Here, we report a rare case of leukocytoclastic vasculitis without immune complexes or cryoglobulinemia in a patient with infective endocarditis, congenital heart disease and a prior mechanical valve replacement. The patient completely recovered following antibiotic therapy and skin lesions disappeared without immune suppression, which suggested infection-mediated vasculitis. While the treatment of leukocytoclastic vasculitis typically involves immunosuppressive therapy, the treatment for infection-mediated vasculitis is eradication of the infection.
ISSN:1054-8807
1879-1336
DOI:10.1016/j.carpath.2017.01.005