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Immunotoxicological consequences of perinatal chemical exposures: a plea for inclusion of immune parameters in reproduction studies

The developing immune system may be especially vulnerable to the toxic effects of immunotoxicants. TCDD, a notorious immunotoxicant, has been shown to produce such effects in rodents as well as in man, and may be considered a prototype developmental immunotoxicant. A number of other chemicals have b...

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Published in:	Toxicology (Amsterdam) 2003-04, Vol.185 (3), p.185-191
Main Authors:	Van Loveren, Henk, Vos, Jeff, Putman, Esther, Piersma, Aldert
Format:	Article
Language:	English
Subjects:	Animals Animals, Newborn - immunology Animals, Newborn - physiology Biological and medical sciences Developmental toxicity Environmental Pollutants - toxicity Female General aspects. Methods Humans Immune System - embryology Immune System - growth & development Immunotoxicity Immunotoxins - toxicity Medical sciences OECD guidelines Polychlorinated Dibenzodioxins - toxicity Pregnancy Pre–postnatal Reproduction - physiology Toxicology Toxicology - methods Toxicology - standards
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container_issue	3
container_start_page	185
container_title	Toxicology (Amsterdam)
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creator	Van Loveren, Henk Vos, Jeff Putman, Esther Piersma, Aldert
description	The developing immune system may be especially vulnerable to the toxic effects of immunotoxicants. TCDD, a notorious immunotoxicant, has been shown to produce such effects in rodents as well as in man, and may be considered a prototype developmental immunotoxicant. A number of other chemicals have been identified that have been shown to affect the developing immune system. Yet, so far there are no immune parameters included in current OECD guidelines for developmental or reproductive toxicity testing. It is recommended that such tests are amended so that also the developing immune system is considered as a potential target of toxicity during developmental stages.
doi_str_mv	10.1016/S0300-483X(02)00608-X
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subjects	Animals Animals, Newborn - immunology Animals, Newborn - physiology Biological and medical sciences Developmental toxicity Environmental Pollutants - toxicity Female General aspects. Methods Humans Immune System - embryology Immune System - growth & development Immunotoxicity Immunotoxins - toxicity Medical sciences OECD guidelines Polychlorinated Dibenzodioxins - toxicity Pregnancy Pre–postnatal Reproduction - physiology Toxicology Toxicology - methods Toxicology - standards
title	Immunotoxicological consequences of perinatal chemical exposures: a plea for inclusion of immune parameters in reproduction studies
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