Suppression of epileptic seizures via Anderson localization

Here we show that brain seizures can be effectively suppressed through random modulation of the brain medium. We use an established mesoscale cortical model in the form of a system of coupled stochastic partial differential equations. We show that by temporal and spatial randomization of parameters...

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Bibliographic Details
Published in:Journal of the Royal Society interface 2017-02, Vol.14 (127), p.20160872-20160872
Main Authors: Zhang, Benjamin J., Chamanzar, Maysamreza, Alam, Mohammad-Reza
Format: Article
Language:English
Subjects:
Anderson Localization
Brain
Brain - physiopathology
Convulsions & seizures
Cortex
Differential equations
Epilepsy
Epilepsy - physiopathology
Humans
Life Sciences–Engineering interface
Localization
Mathematical models
Mesoscale Cortical Model
Models, Neurological
Partial differential equations
Seizing
Seizure Attenuation
Seizures
Stochasticity
Wave attenuation
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Summary:Here we show that brain seizures can be effectively suppressed through random modulation of the brain medium. We use an established mesoscale cortical model in the form of a system of coupled stochastic partial differential equations. We show that by temporal and spatial randomization of parameters governing the firing rates of the excitatory and inhibitory neuron populations, seizure waves can be significantly suppressed. We find that the attenuation is the most effective when applied to the mean threshold potential. The proposed technique can serve as a non-invasive paradigm to mitigate epileptic seizures without knowing the location of the epileptic foci.
ISSN:1742-5689
1742-5662
DOI:10.1098/rsif.2016.0872