TFE3, HSP47, and CREB3 Pathways of the Mammalian Golgi Stress Response

The capacity of each organelle in eukaryotic cells is tightly regulated in accordance with cellular demands by specific regulatory systems, which are generically termed organelle autoregulation. The Golgi stress response is one of the systems of organelle autoregulation and it augments the capacity...

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Bibliographic Details
Published in:Cell Structure and Function 2017, Vol.42(1), pp.27-36
Main Authors: Taniguchi, Mai, Yoshida, Hiderou
Format: Article
Language:English
Subjects:
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism
Cell cycle
Cellular stress response
CREB3
Cyclic AMP Response Element-Binding Protein - metabolism
Enzymes
Golgi apparatus
Golgi Apparatus - metabolism
HSP47
HSP47 Heat-Shock Proteins - metabolism
Humans
Mitochondria
MLX
organelle autoregulation
Proteins
Sensors
Stress, Physiological
TFE3
Transcription factors
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Summary:The capacity of each organelle in eukaryotic cells is tightly regulated in accordance with cellular demands by specific regulatory systems, which are generically termed organelle autoregulation. The Golgi stress response is one of the systems of organelle autoregulation and it augments the capacity of Golgi function if this becomes insufficient (Golgi stress). Recently, several pathways of the mammalian Golgi stress response have been identified, specifically the TFE3, HSP47, and CREB3 pathways. This review summarizes the essential parts of the Golgi stress response from the perspective of the organelle autoregulation.
ISSN:0386-7196
1347-3700
DOI:10.1247/csf.16023