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Surgical Resection for Lymph Node Metastasis After Liver Transplantation for Hepatocellular Carcinoma
Treatment strategies for lymph node (LN) metastasis after liver transplantation (LT) for hepatocellular carcinoma (HCC) have not been studied. The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed. The mean time from LT to LN recurrence was 2.0±1.3 year...
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| Published in: | Anticancer research 2017-02, Vol.37 (2), p.891-896 |
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| Main Authors: | , , , , , , , , , , |
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| Language: | English |
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| container_end_page | 896 |
| container_issue | 2 |
| container_start_page | 891 |
| container_title | Anticancer research |
| container_volume | 37 |
| creator | Ikegami, Toru Yoshizumi, Tomoharu Kawasaki, Jyunji Nagatsu, Akihisa Uchiyama, Hideaki Harada, Noboru Harimoto, Norifumi Itoh, Shinji Motomura, Takashi Soejima, Yuji Maehara, Yoshihiko |
| description | Treatment strategies for lymph node (LN) metastasis after liver transplantation (LT) for hepatocellular carcinoma (HCC) have not been studied.
The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed.
The mean time from LT to LN recurrence was 2.0±1.3 years, and the locations of the LNs recurrences included the phrenic (n=2), common hepatic artery (n=2), inferior vena cava (n=1) and gastric (n=1) regions. Treatments included surgery alone (n=3), surgery followed by chemoradiation (n=1), radiation followed by chemotherapy (n=1), and chemotherapy, radiation and sorafenib (n=1). Although the patients receiving non-surgical treatments (n=3) died within 1.2 years, those who underwent surgical removal of the metastatic LNs survived 11.2 years, 4.5 years and 0.8 years, respectively, without any signs of re-recurrence.
Surgical resection is the only feasible and potentially curative treatment for LN metastasis after LT for HCC. |
| doi_str_mv | 10.21873/anticanres.11395 |
| format | article |
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The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed.
The mean time from LT to LN recurrence was 2.0±1.3 years, and the locations of the LNs recurrences included the phrenic (n=2), common hepatic artery (n=2), inferior vena cava (n=1) and gastric (n=1) regions. Treatments included surgery alone (n=3), surgery followed by chemoradiation (n=1), radiation followed by chemotherapy (n=1), and chemotherapy, radiation and sorafenib (n=1). Although the patients receiving non-surgical treatments (n=3) died within 1.2 years, those who underwent surgical removal of the metastatic LNs survived 11.2 years, 4.5 years and 0.8 years, respectively, without any signs of re-recurrence.
Surgical resection is the only feasible and potentially curative treatment for LN metastasis after LT for HCC.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.11395</identifier><identifier>PMID: 28179348</identifier><language>eng</language><publisher>Greece</publisher><subject>Adult ; Aged ; Antineoplastic Agents - therapeutic use ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Carcinoma, Hepatocellular - therapy ; Chemoradiotherapy - methods ; Feasibility Studies ; Female ; Humans ; Liver - drug effects ; Liver - radiation effects ; Liver - surgery ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Neoplasms - therapy ; Liver Transplantation - methods ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Niacinamide - analogs & derivatives ; Niacinamide - therapeutic use ; Phenylurea Compounds - therapeutic use ; Survival Analysis ; Time Factors ; Treatment Outcome</subject><ispartof>Anticancer research, 2017-02, Vol.37 (2), p.891-896</ispartof><rights>Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-981bc0d33236473a57953728167bfbe187399257e16c9b3b8f576b580cdbad6a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28179348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikegami, Toru</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Kawasaki, Jyunji</creatorcontrib><creatorcontrib>Nagatsu, Akihisa</creatorcontrib><creatorcontrib>Uchiyama, Hideaki</creatorcontrib><creatorcontrib>Harada, Noboru</creatorcontrib><creatorcontrib>Harimoto, Norifumi</creatorcontrib><creatorcontrib>Itoh, Shinji</creatorcontrib><creatorcontrib>Motomura, Takashi</creatorcontrib><creatorcontrib>Soejima, Yuji</creatorcontrib><creatorcontrib>Maehara, Yoshihiko</creatorcontrib><title>Surgical Resection for Lymph Node Metastasis After Liver Transplantation for Hepatocellular Carcinoma</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Treatment strategies for lymph node (LN) metastasis after liver transplantation (LT) for hepatocellular carcinoma (HCC) have not been studied.
The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed.
The mean time from LT to LN recurrence was 2.0±1.3 years, and the locations of the LNs recurrences included the phrenic (n=2), common hepatic artery (n=2), inferior vena cava (n=1) and gastric (n=1) regions. Treatments included surgery alone (n=3), surgery followed by chemoradiation (n=1), radiation followed by chemotherapy (n=1), and chemotherapy, radiation and sorafenib (n=1). Although the patients receiving non-surgical treatments (n=3) died within 1.2 years, those who underwent surgical removal of the metastatic LNs survived 11.2 years, 4.5 years and 0.8 years, respectively, without any signs of re-recurrence.
Surgical resection is the only feasible and potentially curative treatment for LN metastasis after LT for HCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Chemoradiotherapy - methods</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - drug effects</subject><subject>Liver - radiation effects</subject><subject>Liver - surgery</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Neoplasms - therapy</subject><subject>Liver Transplantation - methods</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Niacinamide - analogs & derivatives</subject><subject>Niacinamide - therapeutic use</subject><subject>Phenylurea Compounds - therapeutic use</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpFkM1OwzAQhC0EoqXwAFxQjlxS7Lj-O1YVUKQCEpRzZDsbCEriYCdIfXvcUoq08h48M5r9ELokeJoRKeiNbvvK6tZDmBJCFTtCYyIUSQWj-BiNccZwKjBmI3QWwifGnCtJT9Eok1FGZ3KM4HXw7zGjTl4ggO0r1yal88lq03QfyZMrIHmEXoc4VUjmZQ_xr_qO79rrNnR1rKAPriV0uncW6nqotU8W2tuqdY0-RyelrgNc7PcEvd3drhfLdPV8_7CYr1JLZ7M-VZIYiwtKM8pngmomFKMiluXClAa2JyuVMQGEW2WokSUT3DCJbWF0wTWdoOvf3M67rwFCnzdV2NbRLbgh5ETyiIASxqKU_EqtdyF4KPPOV432m5zgfEc3_6eb7-hGz9U-fjANFAfHH076A1e5eVI</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Ikegami, Toru</creator><creator>Yoshizumi, Tomoharu</creator><creator>Kawasaki, Jyunji</creator><creator>Nagatsu, Akihisa</creator><creator>Uchiyama, Hideaki</creator><creator>Harada, Noboru</creator><creator>Harimoto, Norifumi</creator><creator>Itoh, Shinji</creator><creator>Motomura, Takashi</creator><creator>Soejima, Yuji</creator><creator>Maehara, Yoshihiko</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Surgical Resection for Lymph Node Metastasis After Liver Transplantation for Hepatocellular Carcinoma</title><author>Ikegami, Toru ; Yoshizumi, Tomoharu ; Kawasaki, Jyunji ; Nagatsu, Akihisa ; Uchiyama, Hideaki ; Harada, Noboru ; Harimoto, Norifumi ; Itoh, Shinji ; Motomura, Takashi ; Soejima, Yuji ; Maehara, Yoshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-981bc0d33236473a57953728167bfbe187399257e16c9b3b8f576b580cdbad6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>Chemoradiotherapy - methods</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Liver - drug effects</topic><topic>Liver - radiation effects</topic><topic>Liver - surgery</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Neoplasms - therapy</topic><topic>Liver Transplantation - methods</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Niacinamide - analogs & derivatives</topic><topic>Niacinamide - therapeutic use</topic><topic>Phenylurea Compounds - therapeutic use</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikegami, Toru</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Kawasaki, Jyunji</creatorcontrib><creatorcontrib>Nagatsu, Akihisa</creatorcontrib><creatorcontrib>Uchiyama, Hideaki</creatorcontrib><creatorcontrib>Harada, Noboru</creatorcontrib><creatorcontrib>Harimoto, Norifumi</creatorcontrib><creatorcontrib>Itoh, Shinji</creatorcontrib><creatorcontrib>Motomura, Takashi</creatorcontrib><creatorcontrib>Soejima, Yuji</creatorcontrib><creatorcontrib>Maehara, Yoshihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikegami, Toru</au><au>Yoshizumi, Tomoharu</au><au>Kawasaki, Jyunji</au><au>Nagatsu, Akihisa</au><au>Uchiyama, Hideaki</au><au>Harada, Noboru</au><au>Harimoto, Norifumi</au><au>Itoh, Shinji</au><au>Motomura, Takashi</au><au>Soejima, Yuji</au><au>Maehara, Yoshihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgical Resection for Lymph Node Metastasis After Liver Transplantation for Hepatocellular Carcinoma</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>37</volume><issue>2</issue><spage>891</spage><epage>896</epage><pages>891-896</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Treatment strategies for lymph node (LN) metastasis after liver transplantation (LT) for hepatocellular carcinoma (HCC) have not been studied.
The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed.
The mean time from LT to LN recurrence was 2.0±1.3 years, and the locations of the LNs recurrences included the phrenic (n=2), common hepatic artery (n=2), inferior vena cava (n=1) and gastric (n=1) regions. Treatments included surgery alone (n=3), surgery followed by chemoradiation (n=1), radiation followed by chemotherapy (n=1), and chemotherapy, radiation and sorafenib (n=1). Although the patients receiving non-surgical treatments (n=3) died within 1.2 years, those who underwent surgical removal of the metastatic LNs survived 11.2 years, 4.5 years and 0.8 years, respectively, without any signs of re-recurrence.
Surgical resection is the only feasible and potentially curative treatment for LN metastasis after LT for HCC.</abstract><cop>Greece</cop><pmid>28179348</pmid><doi>10.21873/anticanres.11395</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Anticancer research, 2017-02, Vol.37 (2), p.891-896 |
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| subjects | Adult Aged Antineoplastic Agents - therapeutic use Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Carcinoma, Hepatocellular - therapy Chemoradiotherapy - methods Feasibility Studies Female Humans Liver - drug effects Liver - radiation effects Liver - surgery Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Neoplasms - therapy Liver Transplantation - methods Lymphatic Metastasis Male Middle Aged Neoplasm Recurrence, Local Niacinamide - analogs & derivatives Niacinamide - therapeutic use Phenylurea Compounds - therapeutic use Survival Analysis Time Factors Treatment Outcome |
| title | Surgical Resection for Lymph Node Metastasis After Liver Transplantation for Hepatocellular Carcinoma |
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