Accuracy of FDG-PET/CT in Colorectal Peritoneal Carcinomatosis: Potential Tool for Evaluation of Chemotherapeutic Response

Neoadjuvant chemotherapy may be administered to patients with peritoneal carcinomatosis (PC) of colorectal cancer (CRC) origin. This study evaluated the performance of fluorodeoxyglucose positron-emission tomography (FDG-PET)/computed tomography (CT) in detection of PC from CRC and correlated the mo...

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Bibliographic Details
Published in:Anticancer research 2017-02, Vol.37 (2), p.929-934
Main Authors: Liberale, Gabriel, Lecocq, Céline, Garcia, Camilo, Muylle, Kristof, Covas, Angélique, Deleporte, Amélie, Hendlisz, Alain, Bouazza, Fikri, El Nakadi, Issam, Flamen, Patrick
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms - diagnostic imaging
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Drug Therapy
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Neoadjuvant Therapy
Outcome Assessment (Health Care) - methods
Peritoneal Neoplasms - diagnostic imaging
Peritoneal Neoplasms - secondary
Positron Emission Tomography Computed Tomography - methods
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
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Summary:Neoadjuvant chemotherapy may be administered to patients with peritoneal carcinomatosis (PC) of colorectal cancer (CRC) origin. This study evaluated the performance of fluorodeoxyglucose positron-emission tomography (FDG-PET)/computed tomography (CT) in detection of PC from CRC and correlated the most metabolically active quadrant with the most affected peritoneal area determined during surgery. This retrospective study compared the performance of FDG-PET/CT for PC diagnosis in 26 patients with CRC with histopathologically-confirmed PC with a control group of 26 patients. An FDG-PET/CT score established for each patient diagnosed with PC was compared with the peritoneal cancer index (PCI) performed during surgery. The sensitivity and specificity of FDG-PET/CT for PC detection were 85% (22/26) and 88% (23/26), respectively. The most scored quadrant by FDG-PET/CT corresponded to the most scored quadrant at surgery in 77.3%. FDG-PET/CT may represent a useful tool for evaluating response to neoadjuvant chemotherapy in patients with PC of CRC origin.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11401