Aquaporin-2 membrane targeting: still a conundrum

The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis. In th...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2017-04, Vol.312 (4), p.F744-F747
Main Authors: Olesen, Emma T B, Fenton, Robert A
Format: Article
Language:English
Subjects:
Animals
Aquaporin 2 - metabolism
Arginine Vasopressin - metabolism
Body Water - metabolism
Cell Membrane - metabolism
Cells
Cyclic AMP - metabolism
Epithelial Cells - metabolism
Homeostasis
Hormones
Humans
Kidney Tubules, Collecting - metabolism
Membranes
Peptides
Protein Transport
Receptors, Vasopressin - metabolism
Second Messenger Systems
Water-Electrolyte Balance
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Summary:The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis. In this brief review we assess the role of cyclic adenosine monophosphate (cAMP) and discuss the emerging concept that type 2 AVP receptor (V2R)-mediated AQP2 trafficking is cAMP-independent.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00010.2017