Assessing the effect of 5‐hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin

BACKGROUND 5‐Hydroxymethylfurfural (5‐HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti‐allergic effect of 5‐HMF by investigating some selected comp...

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Bibliographic Details
Published in:Journal of the science of food and agriculture 2017-09, Vol.97 (12), p.3979-3984
Main Authors: Alizadeh, Mohammad, Khodaei, Hamed, Mesgari Abbasi, Mehran, Saleh‐Ghadimi, Sevda
Format: Article
Language:English
Subjects:
5‐HMF
Allergic diseases
Animals
Anti-Allergic Agents - administration & dosage
Antibodies
Biological effects
cytokines
Female
Furaldehyde - administration & dosage
Furaldehyde - analogs & derivatives
Humans
Hydroxymethylfurfural
Hypersensitivity - drug therapy
Hypersensitivity - immunology
Immune response
Immune system
Immunity, Humoral - drug effects
Immunoglobulin E
Immunoglobulin E - immunology
Interferon
Interferon-gamma - immunology
Interleukin 4
Interleukin-4 - immunology
Interleukins
Lymphocytes T
Maillard reaction
Mice
Mice, Inbred BALB C
Ovalbumin
Ovalbumin - immunology
Rodents
Th1 Cells - immunology
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Summary:BACKGROUND 5‐Hydroxymethylfurfural (5‐HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti‐allergic effect of 5‐HMF by investigating some selected components of the immune response in BALB/c mice immunised with ovalbumin (OVA). RESULTS Immunised animals had an increased level of serum total and OVA‐specific antibodies when compared to the control (P < 0.01).We found that the OVA‐induced increase in serum IgE and OVA‐specific IgE were significantly suppressed in the groups treated with 5‐HMF (P < 0.05). Moreover, interleukin‐4 (IL‐4) and interferon gamma (IFN‐γ) were significantly reduced in a dose‐independent manner when compared to the sensitised group (P < 0.05). CONCLUSION 5‐HMF inhibited the up‐regulation of total and OVA‐specific IgE through the suppression of the Th2‐type immune response in immunised BALB/c mice. 5‐HMF could therefore be a novel therapeutic approach for the prevention of IgE‐mediated allergic diseases. © 2017 Society of Chemical Industry
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.8261