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Assessing the effect of 5‐hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin
BACKGROUND 5‐Hydroxymethylfurfural (5‐HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti‐allergic effect of 5‐HMF by investigating some selected comp...
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| Published in: | Journal of the science of food and agriculture 2017-09, Vol.97 (12), p.3979-3984 |
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| Main Authors: | , , , |
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| cited_by | cdi_FETCH-LOGICAL-c3531-7cab2222e5213ba857bd2be590f72f6c5eaf48c28963dc6acfaccb8483ef66743 |
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| cites | cdi_FETCH-LOGICAL-c3531-7cab2222e5213ba857bd2be590f72f6c5eaf48c28963dc6acfaccb8483ef66743 |
| container_end_page | 3984 |
| container_issue | 12 |
| container_start_page | 3979 |
| container_title | Journal of the science of food and agriculture |
| container_volume | 97 |
| creator | Alizadeh, Mohammad Khodaei, Hamed Mesgari Abbasi, Mehran Saleh‐Ghadimi, Sevda |
| description | BACKGROUND
5‐Hydroxymethylfurfural (5‐HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti‐allergic effect of 5‐HMF by investigating some selected components of the immune response in BALB/c mice immunised with ovalbumin (OVA).
RESULTS
Immunised animals had an increased level of serum total and OVA‐specific antibodies when compared to the control (P < 0.01).We found that the OVA‐induced increase in serum IgE and OVA‐specific IgE were significantly suppressed in the groups treated with 5‐HMF (P < 0.05). Moreover, interleukin‐4 (IL‐4) and interferon gamma (IFN‐γ) were significantly reduced in a dose‐independent manner when compared to the sensitised group (P < 0.05).
CONCLUSION
5‐HMF inhibited the up‐regulation of total and OVA‐specific IgE through the suppression of the Th2‐type immune response in immunised BALB/c mice. 5‐HMF could therefore be a novel therapeutic approach for the prevention of IgE‐mediated allergic diseases. © 2017 Society of Chemical Industry |
| doi_str_mv | 10.1002/jsfa.8261 |
| format | article |
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5‐Hydroxymethylfurfural (5‐HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti‐allergic effect of 5‐HMF by investigating some selected components of the immune response in BALB/c mice immunised with ovalbumin (OVA).
RESULTS
Immunised animals had an increased level of serum total and OVA‐specific antibodies when compared to the control (P < 0.01).We found that the OVA‐induced increase in serum IgE and OVA‐specific IgE were significantly suppressed in the groups treated with 5‐HMF (P < 0.05). Moreover, interleukin‐4 (IL‐4) and interferon gamma (IFN‐γ) were significantly reduced in a dose‐independent manner when compared to the sensitised group (P < 0.05).
CONCLUSION
5‐HMF inhibited the up‐regulation of total and OVA‐specific IgE through the suppression of the Th2‐type immune response in immunised BALB/c mice. 5‐HMF could therefore be a novel therapeutic approach for the prevention of IgE‐mediated allergic diseases. © 2017 Society of Chemical Industry</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.8261</identifier><identifier>PMID: 28188638</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>5‐HMF ; Allergic diseases ; Animals ; Anti-Allergic Agents - administration & dosage ; Antibodies ; Biological effects ; cytokines ; Female ; Furaldehyde - administration & dosage ; Furaldehyde - analogs & derivatives ; Humans ; Hydroxymethylfurfural ; Hypersensitivity - drug therapy ; Hypersensitivity - immunology ; Immune response ; Immune system ; Immunity, Humoral - drug effects ; Immunoglobulin E ; Immunoglobulin E - immunology ; Interferon ; Interferon-gamma - immunology ; Interleukin 4 ; Interleukin-4 - immunology ; Interleukins ; Lymphocytes T ; Maillard reaction ; Mice ; Mice, Inbred BALB C ; Ovalbumin ; Ovalbumin - immunology ; Rodents ; Th1 Cells - immunology</subject><ispartof>Journal of the science of food and agriculture, 2017-09, Vol.97 (12), p.3979-3984</ispartof><rights>2017 Society of Chemical Industry</rights><rights>2017 Society of Chemical Industry.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-7cab2222e5213ba857bd2be590f72f6c5eaf48c28963dc6acfaccb8483ef66743</citedby><cites>FETCH-LOGICAL-c3531-7cab2222e5213ba857bd2be590f72f6c5eaf48c28963dc6acfaccb8483ef66743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28188638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alizadeh, Mohammad</creatorcontrib><creatorcontrib>Khodaei, Hamed</creatorcontrib><creatorcontrib>Mesgari Abbasi, Mehran</creatorcontrib><creatorcontrib>Saleh‐Ghadimi, Sevda</creatorcontrib><title>Assessing the effect of 5‐hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin</title><title>Journal of the science of food and agriculture</title><addtitle>J Sci Food Agric</addtitle><description>BACKGROUND
5‐Hydroxymethylfurfural (5‐HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti‐allergic effect of 5‐HMF by investigating some selected components of the immune response in BALB/c mice immunised with ovalbumin (OVA).
RESULTS
Immunised animals had an increased level of serum total and OVA‐specific antibodies when compared to the control (P < 0.01).We found that the OVA‐induced increase in serum IgE and OVA‐specific IgE were significantly suppressed in the groups treated with 5‐HMF (P < 0.05). Moreover, interleukin‐4 (IL‐4) and interferon gamma (IFN‐γ) were significantly reduced in a dose‐independent manner when compared to the sensitised group (P < 0.05).
CONCLUSION
5‐HMF inhibited the up‐regulation of total and OVA‐specific IgE through the suppression of the Th2‐type immune response in immunised BALB/c mice. 5‐HMF could therefore be a novel therapeutic approach for the prevention of IgE‐mediated allergic diseases. © 2017 Society of Chemical Industry</description><subject>5‐HMF</subject><subject>Allergic diseases</subject><subject>Animals</subject><subject>Anti-Allergic Agents - administration & dosage</subject><subject>Antibodies</subject><subject>Biological effects</subject><subject>cytokines</subject><subject>Female</subject><subject>Furaldehyde - administration & dosage</subject><subject>Furaldehyde - analogs & derivatives</subject><subject>Humans</subject><subject>Hydroxymethylfurfural</subject><subject>Hypersensitivity - drug therapy</subject><subject>Hypersensitivity - immunology</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity, Humoral - drug effects</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - immunology</subject><subject>Interferon</subject><subject>Interferon-gamma - immunology</subject><subject>Interleukin 4</subject><subject>Interleukin-4 - immunology</subject><subject>Interleukins</subject><subject>Lymphocytes T</subject><subject>Maillard reaction</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Ovalbumin</subject><subject>Ovalbumin - immunology</subject><subject>Rodents</subject><subject>Th1 Cells - immunology</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kc9qFTEUh4Mo9ra68AUk4KZdTJs_M5nM8lKsWgou1HXIZE68uUySazLTOouCj-Az-iTmelsXgofAgZzvfBz4IfSKknNKCLvYZqvPJRP0CVpR0rUVIZQ8RasyY1VDa3aEjnPeEkK6Tojn6IhJKqXgcoXu1zlDzi58xdMGMFgLZsLR4ubXj5-bZUjx--Jh2iyjnVN5esQx4AxjwWDAJvpdDBCmvN9x3s8BcIJcPosWu4C9M3AYuFwW7ty0wfFWj_3sXXiBnlk9Znj50E_Ql6u3ny_fVzcf3324XN9UhjecVq3RPSsFDaO817Jp-4H10HTEtswK04C2tTRMdoIPRmhjtTG9rCUHK0Rb8xN0evDuUvw2Q56Ud9nAOOoAcc6KStE2vGMtL-ibf9BtnFMo1ylagJpxLttCnR0ok2LOCazaJed1WhQlap-J2mei9pkU9vWDce49DH_JxxAKcHEA7twIy_9N6vrT1fqP8jdXSZn_</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Alizadeh, Mohammad</creator><creator>Khodaei, Hamed</creator><creator>Mesgari Abbasi, Mehran</creator><creator>Saleh‐Ghadimi, Sevda</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>Assessing the effect of 5‐hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin</title><author>Alizadeh, Mohammad ; Khodaei, Hamed ; Mesgari Abbasi, Mehran ; Saleh‐Ghadimi, Sevda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-7cab2222e5213ba857bd2be590f72f6c5eaf48c28963dc6acfaccb8483ef66743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>5‐HMF</topic><topic>Allergic diseases</topic><topic>Animals</topic><topic>Anti-Allergic Agents - administration & dosage</topic><topic>Antibodies</topic><topic>Biological effects</topic><topic>cytokines</topic><topic>Female</topic><topic>Furaldehyde - administration & dosage</topic><topic>Furaldehyde - analogs & derivatives</topic><topic>Humans</topic><topic>Hydroxymethylfurfural</topic><topic>Hypersensitivity - drug therapy</topic><topic>Hypersensitivity - immunology</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity, Humoral - drug effects</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - immunology</topic><topic>Interferon</topic><topic>Interferon-gamma - immunology</topic><topic>Interleukin 4</topic><topic>Interleukin-4 - immunology</topic><topic>Interleukins</topic><topic>Lymphocytes T</topic><topic>Maillard reaction</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Ovalbumin</topic><topic>Ovalbumin - immunology</topic><topic>Rodents</topic><topic>Th1 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alizadeh, Mohammad</creatorcontrib><creatorcontrib>Khodaei, Hamed</creatorcontrib><creatorcontrib>Mesgari Abbasi, Mehran</creatorcontrib><creatorcontrib>Saleh‐Ghadimi, Sevda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alizadeh, Mohammad</au><au>Khodaei, Hamed</au><au>Mesgari Abbasi, Mehran</au><au>Saleh‐Ghadimi, Sevda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the effect of 5‐hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J Sci Food Agric</addtitle><date>2017-09</date><risdate>2017</risdate><volume>97</volume><issue>12</issue><spage>3979</spage><epage>3984</epage><pages>3979-3984</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><abstract>BACKGROUND
5‐Hydroxymethylfurfural (5‐HMF) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti‐allergic effect of 5‐HMF by investigating some selected components of the immune response in BALB/c mice immunised with ovalbumin (OVA).
RESULTS
Immunised animals had an increased level of serum total and OVA‐specific antibodies when compared to the control (P < 0.01).We found that the OVA‐induced increase in serum IgE and OVA‐specific IgE were significantly suppressed in the groups treated with 5‐HMF (P < 0.05). Moreover, interleukin‐4 (IL‐4) and interferon gamma (IFN‐γ) were significantly reduced in a dose‐independent manner when compared to the sensitised group (P < 0.05).
CONCLUSION
5‐HMF inhibited the up‐regulation of total and OVA‐specific IgE through the suppression of the Th2‐type immune response in immunised BALB/c mice. 5‐HMF could therefore be a novel therapeutic approach for the prevention of IgE‐mediated allergic diseases. © 2017 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>28188638</pmid><doi>10.1002/jsfa.8261</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of the science of food and agriculture, 2017-09, Vol.97 (12), p.3979-3984 |
| issn | 0022-5142 1097-0010 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | 5‐HMF Allergic diseases Animals Anti-Allergic Agents - administration & dosage Antibodies Biological effects cytokines Female Furaldehyde - administration & dosage Furaldehyde - analogs & derivatives Humans Hydroxymethylfurfural Hypersensitivity - drug therapy Hypersensitivity - immunology Immune response Immune system Immunity, Humoral - drug effects Immunoglobulin E Immunoglobulin E - immunology Interferon Interferon-gamma - immunology Interleukin 4 Interleukin-4 - immunology Interleukins Lymphocytes T Maillard reaction Mice Mice, Inbred BALB C Ovalbumin Ovalbumin - immunology Rodents Th1 Cells - immunology |
| title | Assessing the effect of 5‐hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin |
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