Alkaline Phosphatase: A Biomarker of Cardiac Function in Pediatric Patients

Myocardial dysfunction and heart failure are common in pediatric patients with congenital and acquired heart disease. Alkaline phosphatase (AP) has been suggested as a biomarker for myocardial dysfunction after Fontan operation. We hypothesized that pediatric patients with myocardial dysfunction req...

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Bibliographic Details
Published in:Pediatric cardiology 2017-04, Vol.38 (4), p.762-769
Main Authors: Makil, Elizabeth S., Tang, Xinyu, Frazier, Elizabeth A., Collins, R. Thomas
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Biomarkers - blood
Cardiac patients
Cardiac Surgery
Cardiology
Child
Child, Preschool
Children
Comparative analysis
Female
Genetic disorders
Health aspects
Heart
Heart Defects, Congenital - blood
Heart Defects, Congenital - surgery
Heart diseases
Heart Failure - blood
Heart Failure - surgery
Heart Transplantation
Humans
Infant
Male
Medicine
Medicine & Public Health
Original Article
Pediatric cardiology
Phosphatases
Retrospective Studies
Transplantation
Vascular Surgery
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Summary:Myocardial dysfunction and heart failure are common in pediatric patients with congenital and acquired heart disease. Alkaline phosphatase (AP) has been suggested as a biomarker for myocardial dysfunction after Fontan operation. We hypothesized that pediatric patients with myocardial dysfunction requiring orthotopic heart transplant (OHT) have diminished AP compared to normal. A retrospective review was performed in all patients who underwent OHT at Arkansas Children’s Hospital between January 2007 and October 2012. Anatomic diagnoses, therapeutic interventions, and ventricular ejection fraction (EF) were recorded. Z scores for AP levels in the study group were determined by comparing the observed AP levels to age- and gender-matched normative values. T tests were performed to compare the mean AP Z score prior to and after OHT. p values
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-017-1577-x