Serum uric acid to creatinine ratio: A predictor of incident chronic kidney disease in type 2 diabetes mellitus patients with preserved kidney function

Background: Serum uric acid has shown to be a predictor of renal disease progression in most but not all studies. This study aims to test whether renal function-normalized serum uric acid is superior to serum uric acid as the predictor of incident chronic kidney disease in type 2 diabetes mellitus p...

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Published in:Diabetes & vascular disease research 2017-05, Vol.14 (3), p.221-225
Main Authors: Gu, Liubao, Huang, Liji, Wu, Haidi, Lou, Qinglin, Bian, Rongwen
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Chi-Square Distribution
China - epidemiology
Creatinine - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Diabetic Nephropathies - diagnosis
Diabetic Nephropathies - epidemiology
Diabetic Nephropathies - physiopathology
Disease Progression
Female
Glomerular Filtration Rate
Humans
Incidence
Kidney - physiopathology
Longitudinal Studies
Male
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - physiopathology
Retrospective Studies
Risk Assessment
Risk Factors
Uric Acid - blood
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Summary:Background: Serum uric acid has shown to be a predictor of renal disease progression in most but not all studies. This study aims to test whether renal function-normalized serum uric acid is superior to serum uric acid as the predictor of incident chronic kidney disease in type 2 diabetes mellitus patients. Methods: In this study, 1339 type 2 diabetes mellitus patients with estimated glomerular filtration rate ⩾60 mL/min/1.73 m2 and normouricemia were included. Renal function-normalized serum uric acid was calculated using serum uric acid/creatinine. Cox regression analysis was used to estimate the association between serum uric acid, renal function-normalized serum uric acid and incident chronic kidney disease. Results: In total, 74 (5.53%) patients developed to chronic kidney disease 3 or greater during a median follow-up of 4 years, with older ages, longer diabetes duration and lower estimated glomerular filtration rate at baseline. The decline rate of estimated glomerular filtration rate was positively correlated with serum uric acid/creatinine (r = 0.219, p 
ISSN:1479-1641
1752-8984
DOI:10.1177/1479164116680318