Retinal angiomatous proliferation

Abstract Retinal angiomatous proliferation (RAP) is a unique variant of neovascular age-related macular degeneration. Published studies have estimated that up to 15% of patients with neovascular age-related macular degeneration have RAP. Clinical features frequently associated with RAP include bilat...

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Bibliographic Details
Published in:Survey of ophthalmology 2017-07, Vol.62 (4), p.462-492
Main Authors: Tsai, Andrew S.H., FRCOphth, FAMS, Cheung, Ning, MD, FRANZCO, Gan, Alfred T.L., MSc, Jaffe, Glenn J., MD, Sivaprasad, Sobha, DM, FRCSEd, Wong, Tien Yin, MPH, FRCSEd, FRANZCO, PhD, Cheung, Chui Ming Gemmy, MCI, FRCOphth
Format: Article
Language:English
Subjects:
age-related macular degeneration
anti-vascular endothelial growth factor
choroidal neovascularization
Fluorescein Angiography - methods
fundus fluorescein angiography
Fundus Oculi
Global Health
Humans
Incidence
Ophthalmology
optical coherence tomography
photodynamic therapy
pigment epithelial detachment
Retina - pathology
retinal angiomatous proliferation
Retinal Neovascularization - classification
Retinal Neovascularization - diagnosis
Retinal Neovascularization - epidemiology
Tomography, Optical Coherence - methods
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Summary:Abstract Retinal angiomatous proliferation (RAP) is a unique variant of neovascular age-related macular degeneration. Published studies have estimated that up to 15% of patients with neovascular age-related macular degeneration have RAP. Clinical features frequently associated with RAP include bilateral disease, presence of pigment epithelial detachments, and reticular pseudodrusen. RAP is more frequently associated with the development of retinal pigment epithelial tears and geographic atrophy that can lead to severe vision loss. Recent advances in retinal and choroidal imaging technology have furthered our understanding of RAP. Although indocyanine green angiography remains the gold standard diagnostic tool, optical coherence tomography has improved the precision by which neovascular age-related macular degeneration with RAP lesions can be diagnosed, staged, and monitored. Anti-vascular endothelial growth factor therapy is currently the first line of treatment. Other treatment options including combination of photodynamic therapy with antiangiogenic agent intravitreal injections or corticosteroids may also achieve a reasonable therapeutic outcome; however, RAP may portend a more guarded visual prognosis than typical choroidal neovascularization because of variable treatment response and dependence on the disease stage. Future basic and clinical research is needed to clarify the pathophysiology, definition and classification, optimal treatment regimen, and long-term outcome of RAP.
ISSN:0039-6257
1879-3304
DOI:10.1016/j.survophthal.2017.01.008