Polyomavirus BK and JC in individuals with chronic kidney failure, kidney transplantation, and healthy controls

Highlights • Oral fluids are equally efficient to detect BKV and JCV compared to urine and blood. • Oral fluids enhance positive screening of BKV and JCV in people who cannot urinate. • This was the first study to detect and quantify BKV and JCV in gingival fluid. • The salivary glands are probably...

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Bibliographic Details
Published in:Journal of clinical virology 2017-04, Vol.89, p.5-9
Main Authors: Castro, Talita, Fink, Maria Cristina Domingues, Figueiredo, Marilia, Braz-Silva, Paulo Henrique, Pannuti, Cláudio Mendes, Ortega, Karem Lopez, Gallottini, Marina
Format: Article
Language:English
Subjects:
Adult
Aged
Allergy and Immunology
BK virus
BK Virus - isolation & purification
Blood - virology
Chronic kidney failure
Female
Gingival crevicular fluid
Humans
Infectious Disease
JC virus
JC Virus - isolation & purification
Kidney Failure, Chronic - complications
Kidney transplantation
Kidney Transplantation - adverse effects
Male
Middle Aged
Mouth - virology
Polyomavirus Infections - epidemiology
Polyomavirus Infections - virology
Real-Time Polymerase Chain Reaction
Retrospective Studies
Saliva
Tumor Virus Infections - epidemiology
Tumor Virus Infections - virology
Urine - virology
Viral Load - methods
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Summary:Highlights • Oral fluids are equally efficient to detect BKV and JCV compared to urine and blood. • Oral fluids enhance positive screening of BKV and JCV in people who cannot urinate. • This was the first study to detect and quantify BKV and JCV in gingival fluid. • The salivary glands are probably a reservoir of BKV and JCV. • High concentration of BKV and JCV in saliva suggests a transmission by this route.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2017.02.003