What is the clinical evidence on regenerative medicine in intervertebral disc degeneration?

Purpose This review aims to explore and summarize the current clinical evidence about the use of regenerative medicine such as mesenchymal stem cells or platelet-rich plasma in intervertebral disc regeneration, in order to clarify the state of art of these novel approaches. Materials and methods We...

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Bibliographic Details
Published in:Musculoskeletal surgery 2017-08, Vol.101 (2), p.93-104
Main Authors: Basso, M., Cavagnaro, L., Zanirato, A., Divano, S., Formica, C., Formica, M., Felli, L.
Format: Article
Language:English
Subjects:
Clinical trials
Evidence-Based Medicine
Humans
Intervertebral Disc Degeneration - therapy
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Mesenchymal Stem Cell Transplantation
Orthopedics
Physiological aspects
Platelet-Rich Plasma
Regenerative Medicine
Review
Skin & tissue grafts
Stem cells
Surgical Orthopedics
Tissue engineering
Transplantation
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Summary:Purpose This review aims to explore and summarize the current clinical evidence about the use of regenerative medicine such as mesenchymal stem cells or platelet-rich plasma in intervertebral disc regeneration, in order to clarify the state of art of these novel approaches. Materials and methods We performed a research of the available literature about regenerative medicine strategies aiming to prevent intervertebral disc degeneration. All preclinical trials and in vitro studies were excluded. Only clinical trials were critically analysed. Results The manuscript selection produced a total of 7 articles concerning the use of regenerative therapies in intervertebral disc degeneration, covering the period between 2010 and 2016. Articles selected were 4 about the injection of mesenchymal stem cells-related results and 3 using platelet-rich plasma. The total population of patients treated with regenerative medicine strategies were 104 patients. Conclusions Regenerative medicine, such as the use of mesenchymal stem cells or platelet-rich plasma, in intradiscal disc degeneration has shown preclinical and clinical positive results. Randomized clinical trials studying the potential of MSCs intradiscal injection have not been conducted, and PRP effect has been studied only preliminarily. Additional more powered high-quality studies are needed to really appreciate the long-term safety and efficacy of regenerative medicine approaches in IDD.
ISSN:2035-5106
2035-5114
DOI:10.1007/s12306-017-0462-3