Associating genetic variation at Perilipin 1, Complement Factor D and Adiponectin loci to the bone health status in North Indian population

Osteoporosis, the most common bone metabolic disease affecting nearly 200 million people worldwide is under the strong influence of genetic components. Simultaneously, adipogenesis and osteogenesis are two highly coordinated processes imperative for the maintenance of bone quality and quantity, wher...

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Bibliographic Details
Published in:Gene 2017-04, Vol.610, p.80-89
Main Authors: Sandhu, Harkirat Singh, Puri, Sanjeev, Sharma, Rubina, Sokhi, Jasmine, Singh, Gagandeep, Matharoo, Kawaljit, Bhanwer, AJS
Format: Article
Language:English
Subjects:
Adipogenesis
Adiponectin
Adiponectin - genetics
Adult
Aged
Bone and Bones - metabolism
Complement Factor D
Complement Factor D - genetics
Epistasis, Genetic
Fats - metabolism
Female
Genetic variants
Haplotype
Humans
India - epidemiology
Male
Middle Aged
North India
Nucleic Acid Conformation
Osteogenesis
Osteoporosis - epidemiology
Osteoporosis - genetics
Perilipin 1
Perilipin-1 - genetics
Polymorphism, Single Nucleotide
RNA Stability
RNA, Messenger - chemistry
Young Adult
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Summary:Osteoporosis, the most common bone metabolic disease affecting nearly 200 million people worldwide is under the strong influence of genetic components. Simultaneously, adipogenesis and osteogenesis are two highly coordinated processes imperative for the maintenance of bone quality and quantity, where any perturbation leads to pathological conditions of obesity, osteopenia and osteoporosis. To delineate this adipogenic-osteogenic connection, a total of 254 cases (T-score
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2017.02.009