Elevated cholesterol levels have a poor prognosis in a cholestasis scenario

Cholestasis results from defective bile flow through the biliary ducts leading to the accumulation of bile acids (BAs) in hepatocytes and serum. It has been seen that cholestasis is associated with hypercholesterolemia, which is a prerequisite for gallstone formation and primary biliary cirrhosis, b...

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Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2017-01, Vol.31 (1), p.1-6
Main Authors: Nuño‐Lámbarri, Natalia, Barbero‐Becerra, Varenka J, Uribe, Misael, Chávez‐Tapia, Norberto C
Format: Article
Language:English
Subjects:
Apoptosis
Bile
bile acids
Bile Acids and Salts - blood
Cell Membrane - metabolism
Cell Membrane - pathology
cholestasis
Cholestasis - blood
Cholestasis - diagnosis
Cholestasis - etiology
Cholestasis - pathology
cholesterol
Cholesterol - blood
Gallbladder diseases
Hepatocytes - metabolism
Hepatocytes - pathology
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - complications
Hypercholesterolemia - diagnosis
Hypercholesterolemia - pathology
Inflammation Mediators - blood
Mitochondria, Liver - metabolism
Mitochondria, Liver - pathology
Mitochondrial Membranes - metabolism
Mitochondrial Membranes - pathology
Oxidative Stress
Prognosis
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Summary:Cholestasis results from defective bile flow through the biliary ducts leading to the accumulation of bile acids (BAs) in hepatocytes and serum. It has been seen that cholestasis is associated with hypercholesterolemia, which is a prerequisite for gallstone formation and primary biliary cirrhosis, being some of the most common gastrointestinal disorders in Western societies. Cytotoxic BAs induce proinflammatory mediators, oxidative stress, and apoptosis in hepatocytes, whereas cytoprotective BAs prevent them; they can also modify the plasmatic membrane structure of cells or mitochondrial outer membrane properties as well as the distribution of cholesterol, altering various proteins involved in BAs homeostasis.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.21831