Postnatal Organ Development as a Complicating Factor in Juvenile Toxicity Studies in Rats

Toxicologic pathologists must evaluate tissues of immature animals from a number of types of nonclinical toxicity studies. The pathologist who is familiar with normal postnatal organ development is in a better position to appropriately detect and differentiate between abnormal, delayed, or precociou...

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Published in:Toxicologic pathology 2017-01, Vol.45 (1), p.248-252
Main Authors: Picut, Catherine A., Parker, George A.
Format: Article
Language:English
Subjects:
Aging - pathology
Aging - physiology
Animals
Morphogenesis
Organ Specificity
Pathology - methods
Pathology - standards
Rats
Toxicity Tests - methods
Toxicity Tests - standards
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description Toxicologic pathologists must evaluate tissues of immature animals from a number of types of nonclinical toxicity studies. The pathologist who is familiar with normal postnatal organ development is in a better position to appropriately detect and differentiate between abnormal, delayed, or precocious development. Vacuolation and apoptosis in multiple tissue types are normal components of development that could influence the interpretation of some tissues. Unique postnatal features such as the germal matrix in the brain, gonocytes in the testes, and saccules in the lung may complicate the histopathological evaluation. With the knowledge of normal organ development and critical windows therein, it is possible to design targeted studies to identify xenobiotic toxicity.
doi_str_mv 10.1177/0192623316671609
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subjects Aging - pathology
Aging - physiology
Animals
Morphogenesis
Organ Specificity
Pathology - methods
Pathology - standards
Rats
Toxicity Tests - methods
Toxicity Tests - standards
title Postnatal Organ Development as a Complicating Factor in Juvenile Toxicity Studies in Rats
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