Exposure to bifenthrin disrupts the development of testis in male Sebastiscus marmoratus

• Published in: Acta oceanologica Sinica 2017-02, Vol.36 (2), p.57-61
• Main Authors: Li, Jinshou, Luo, Fen, Liu, Liyue, Ruan, Junfeng, Wang, Nannan
• Format: Article
• Language: English
• Subjects: 17β-Estradiol; 17β-雌二醇; Apoptosis; Caspase-3; Climatology; Earth and Environmental Science; Earth Sciences; Ecology; Engineering Fluid Dynamics; Environmental Chemistry; Exposure; Fish; Horticulture; Insecticides; Invertebrates; Marine; Marine & Freshwater Sciences; Oceanography; Proteins; Pyrethroids; Sebastiscus marmoratus; Sex hormones; Spermatogenesis; Spermatozoa; Testes; Testosterone; Toxicity; TUNEL法; 拟除虫菊酯类杀虫剂; 睾丸发育; 精巢发育; 联苯菊酯; 雄性
• ISSN: 0253-505X; 1869-1099
• DOI: 10.1007/s13131-017-1001-7

Bifenthrin（BF） is a pyrethroid insecticide that is widely used in agriculture, horticulture, and for residential purposes. However, few studies addressing the reproductive toxicity of BF on fishes are available. The present study was conducted to investigate the effects of BF on testicular development in Sebastiscus marmoratus and to gain insight into its mechanism. After exposure to 1, 10 and 100 ng/L BF for 50 days, there was a reduced number of mature sperm and an abundance of the late stages of spermatocysts in the testes. The levels of 17β-estradiol and testosterone were decreased significantly after BF exposure. The activity of caspase-3 was increased in a dosedependent manner after BF exposure, TUNEL assay indicated that BF exposure resulted in the occurrence of apoptosis in the testes, which might be main reason for the inhibition of spermatogenesis.